Table III.
Differentially expressed proteins in glycolysis and mitochondrial oxidative phosphorylation identified by iTRAQ.
| Process | Protein accession no. | Gene | Protein description | RM-PAX2 RM-WPI ratio | Regulated type | P-value |
|---|---|---|---|---|---|---|
| Glycolysis | P17809 | Slc2a1, Glut-1, Glut1 | Solute carrier family 2, facilitated glucose transporter member 1 | 0.86 | - | 0.3308 |
| P17710 | Hk1 | Hexokinase-1 | 0.91 | - | 0.1620 | |
| O08528 | Hk2 | Hexokinase-2 | 0.83 | - | 0.2196 | |
| Q3TRM8 | Hk3 | Hexokinase-3 | NA | NA | NA | |
| Q8VDL4 | Adpgk | ADP-dependent glucokinase | 0.87 | - | 0.2782 | |
| P06745 | Gpi | Glucose-6-phosphate isomerase | 1.05 | - | 0.2221 | |
| P12382 | Pfkl | ATP-dependent 6-phosphofructokinase, liver type | 0.77 | - | 0.2985 | |
| P47857 | Pfkm | ATP-dependent 6-phosphofructokinase, muscle type | 0.73 | - | 0.1779 | |
| Q9WUA3 | Pfkp | ATP-dependent 6-phosphofructokinase, platelet type | 1.15 | - | 0.1916 | |
| P05063 | Aldoc | Fructose-bisphosphate aldolase C | 0.71 | - | 0.0788 | |
| P05064 | Aldoa | Fructose-bisphosphate aldolase A | 0.85 | - | 0.2419 | |
| P17751 | Tpi1 | Triosephosphate isomerase | 0.83 | - | 0.0141 | |
| P17182 | Eno1 | α-enolase | 0.79 | - | 0.1339 | |
| P21550 | Eno3 | β-enolase | 0.95 | - | 0.4925 | |
| P09411 | Pgk1 | Phosphoglycerate kinase 1 | 0.97 | - | 0.8095 | |
| P09041 | Pgk2 | Phosphoglycerate kinase 2 | 0.99 | - | 0.9302 | |
| Q9DBJ1 | Pgam1 | Phosphoglycerate mutase 1 | 0.87 | - | 0.0648 | |
| P52480 | Pkm | Pyruvate kinase PKM | 0.77 | Down | 0.0236 | |
| Mitochondrial electron transport chain | Q8CIM7 | Cyp2d26 | Cytochrome P450 2D26 | 2.44 | Up | 0.0004 |
| Q64459 | Cyp3a11 | Cytochrome P450 3A11 | 2.20 | Up | 0.0498 | |
| P56395 | Cyb5a | Cytochrome b5 | 1.93 | Up | 0.0278 | |
| P48771 | Cox7a2 | Cytochrome c oxidase subunit 7A2, mitochondrial | 1.31 | Up | 0.0175 | |
| Q91VR2 | Atp5f1c | ATP synthase subunit gamma, mitochondrial | 1.29 | Up | 0.0224 | |
| Q61941 | Nnt | NAD(P) transhydrogenase, mitochondrial | 1.26 | Up | 0.0099 | |
| Q99LC3 | Ndufa10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | 1.26 | Up | 0.0453 | |
| Q9D855 | Uqcrb | Cytochrome b-c1 complex subunit 7 | 1.25 | Up | 0.0130 | |
| P19783 | Cox4i1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 1.23 | Up | 0.0107 | |
| Q9Z1P6 | Ndufa7 | NADH dehydrogenase [ubiquinone] 1α subcomplex subunit 7 | 1.25 | Up | 0.0396 | |
| Tricarboxylic acid cycle | Q9CZU6 | Cs | Citrate synthase, mitochondrial | 1.14 | - | 0.1691 |
| Q9WUM5 | Suclg1 | Succinyl-CoA ligase [ADP/GDP-forming] subunit α, mitochondrial | 1.55 | Up | 0.0112 | |
| Q8K2B3 | Sdha | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | 1.23 | Up | 0.0374 | |
| P97807 | Fh, Fh1 | Fumarate hydratase, mitochondrial | 1.21 | - | 0.0524 |
Up, upregulated; Down, downregulated.