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. 2020 Feb 10;15(2):e0228772. doi: 10.1371/journal.pone.0228772

Fig 5. Detection of specific IgG and IgM antibodies in early LD.

Fig 5

GC-FP was used to evaluate serum from a patient with early LD but a false-negative result based on the STTT. The mean GC-FP signal ± Standard Error of the Mean for IgG detection and additional IgM detection is plotted for 16 antigen targets. IgG against 2 out of 16 targets were detected with significantly higher signal than the negative control: BBA65, BBA69. Additional detection of IgM antibodies led to amplified signal for those two targets and 8 more targets: P58, BmpA, P41, ErpL, VlsE, ErpY, BBA70, and BBA73, or a total of 10 out of 16 detected targets (****, p<0.0001; ***, p<0.001; **, p<0.01; *, p<0.05; 2-way ANOVA followed by Fisher’s LSD test for multiple comparisons).