Table 1.
Baseline, 1-, and 3-Year Follow-up Characteristics of All Patients With Primary Aldosteronism
| Patient Characteristics (n = 148) | No. | Baseline | After 1 Y | P | After 3 Y | P |
|---|---|---|---|---|---|---|
| Sex, F/M | 148 | 56/92 | -- | NC | -- | NC |
| Age, y | 148 | 51 [45; 59] | -- | NC | -- | NC |
| BMI, kg/m2 | 148 | 27.4 [24.3; 31.2] | 27.4 [24.0; 30.5] | 0.332 | 27.8 [24.5; 30.5] | 0.339 |
| Aldosterone, ng/L | 148 | 170 [107; 263] | 129 [59; 239] | 0.109 | 155 [83; 279] | 0.986 |
| Plasma renin, mU/L | 148 | 4.1 [2.1; 8.5] | 16.0 [6.6; 28.1] | <0.001 | 19.6 [7.2; 39.9] | <0.001 |
| SBP, mm Hg | 148 | 150 [137; 166] | 133 [123; 143] | <0.001 | 131 [121; 141] | <0.001 |
| DBP, mm Hg | 148 | 93 [84; 102] | 87 [80; 93] | <0.001 | 86 [79; 93] | <0.001 |
| 24-h SBP, mm Hg | 114 | 144 [137; 154] | 132 [123; 139] | <0.001 | 130 [121; 138] | <0.001 |
| 24-h DBP, mm Hg | 114 | 93 [83; 99] | 82 [76; 87] | <0.001 | 82 [77; 87] | <0.001 |
| DDD, n | 148 | 2.5 [1.0; 4.0] | 1.7 [0.5; 3.6] | 0.004 | 1.7 [0.5; 3.0] | <0.001 |
| Serum sodium, mmol/L | 148 | 141 [139; 142] | 139 [137; 140] | <0.001 | 140 [138; 141] | 0.001 |
| Serum potassium, mmol/L | 148 | 3.5 [3.2; 3.8] | 4.1 [3.9; 4.4] | <0.001 | 4.4 [4.1; 4.6] | <0.001 |
| Serum creatinine, mg/dL | 148 | 0.9 [0.7; 1.0] | 1.0 [0.8; 1.2] | <0.001 | 1.0 [0.9; 1.2] | <0.001 |
| GFR, mL/min/1.73 m2 | 148 | 85 [72; 100] | 73 [59; 84] | <0.001 | 69 [58; 81] | <0.001 |
| HDL-C, mg/dL | 148 | 56 [45; 69] | 50 [41; 64] | <0.001 | 53 [44; 64] | <0.001 |
| LDL-C, mg/dL | 148 | 120 [98; 148] | 121 [95; 143] | 0.448 | 119 [85; 143] | 0.603 |
| Triglycerides, mg/dL | 148 | 95 [67; 135] | 119 [82; 175] | <0.001 | 120 [83; 177] | <0.001 |
| Total cholesterol, mg/dL | 148 | 193 [173; 221] | 191 [168; 223] | 0.807 | 191 [163; 224] | 0.859 |
| FPG, mg/dL | 148 | 98 [91; 110] | 99 [91; 106] | 0.139 | 99 [92; 109] | 0.197 |
| HbA1c, % | 130 | 5.3 [5.1; 5.7] | 5.5 [5.2; 5.8] | <0.001 | 5.4 [5.2; 5.8] | <0.001 |
| proBNP, pg/mL | 137 | 86 [52; 185] | 52 [29; 93] | <0.001 | 47 [26; 120] | <0.001 |
| Proteinuria, mg/d | 148 | 143 [109; 210] | 104 [83; 126] | <0.001 | 112 [85; 134] | <0.001 |
| 24-h urinary potassium, mmol/d | 148 | 87 [67; 125] | 68 [52; 87] | <0.001 | 69 [49; 84] | <0.001 |
| 24-h urinary sodium, mmol/d | 148 | 184 [146; 253] | 177 [128; 238] | 0.027 | 182 [136; 240] | 0.126 |
| Estimated salt intake, g/d | 148 | 10.8 [8.5; 14.8] | 10.4 [7.5; 13.9] | 0.027 | 10.6 [8.0; 14.0] | 0.126 |
Data are given as median, and 25th and 75th percentile in square brackets. Significance is marked in bold. Comparisons to baseline values were performed by Wilcoxon signed-rank test.
Abbreviations: 24-h DBP, 24-hour diastolic blood pressure; 24-h SBP, 24-hour systolic blood pressure; DBP, diastolic blood pressure; DDD, defined daily doses of antihypertensive medication; FPG, fasting plasma glucose; GFR, glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; NC, not calculated; proBNP, pro b-type natriuretic peptide; SBP, systolic blood pressure.