KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit hSETD1A	Bethyl	Cat# A300-289
Rabbit Histone H3	Abcam	Cat# ab1791
Rabbit Mef2c/a	Abcam	Cat# ab64644
Mouse NeuN	Millipore	Cat# MAB377
Rabbit NeuN	Millipore	Cat# ABN78
Mouse Tau-1	Millipore	Cat# MAB3420
Rabbit Tbr2	Abcam	Cat# AB183991
Rabbit GFP	Invitrogen	Cat# A-11122
Mouse Parvalbumin	Swant	Cat# 235
Mouse GFAP	Millipore	Cat# MAB360
Rat PH-3	Abcam	Cat# AB10543
Rabbit RFP	Rockland	Cat# 600-401-379
Rabbit VIP	Immunostar	Cat# 20077
Mouse Reelin	Millipore	Cat# MAB5364
Mouse SST	Millipore	Cat# MAB354
Rabbit hSET1	Abcam	Cat# ab70378
Rabbit Mef2	SantaCruz Biotechnology	Cat# sc-313
Rabbit H3K4me1	Abcam	Cat# ab8895
Mouse H3K4me2	Millipore	Cat# 05-1338
Rabbit H3K4me3	Millipore	Cat# 04-745
Rabbit H3K27ac	Active Motif	Cat# 39133
Rabbit LSD1	Abcam	Cat# ab17721
Mouse anti-rabbit IgG light chain (HRP)	Abcam	Cat# ab99697
Goat anti-Mouse IgG (H+L) Secondary Antibody, Alexa Fluor 488	Thermo Fisher Scientific	Cat# A-11001
Goat anti-Mouse IgG (H+L) Secondary Antibody, Alexa Fluor 568	Thermo Fisher Scientific	Cat# A-11004
Goat anti-Rabbit IgG (H+L) Secondary Antibody, Alexa Fluor 488	Thermo Fisher Scientific	Cat# A-11008
Goat anti-Rabbit IgG (H+L) Secondary Antibody, Alexa Fluor 568	Thermo Fisher Scientific	Cat# A-11011
Goat anti-Rat IgG (H+L) Secondary Antibody, Alexa Fluor 488	Thermo Fisher Scientific	Cat# A-11006
Goat Anti-Rabbit IgG (H+L)-HRP Conjugate	Biorad	Cat# 1706515
Normal Rabbit Serum	Jackson Immuno Research	Cat# 011-000-120
Bacterial and Virus Strains
rAAV2/hSynapsin/EGFP	Addgene	Cat# 50465-AAV2
Chemicals, Peptides, and Recombinant Proteins
Lipofectamine 3000	ThermoFisher Scentific	Cat# L3000008
Lipofectamine 2000	ThermoFisher Scentific	Cat# 11668027
RN-1	Tocris	Cat# 10010494
PBIT	Sigma	Cat# SML1058
IOX-1	Sigma	Cat# SML0067
tranylcypromine	Cayman Chemical	Cat# 10010494
ORY-1001	Cayman Chemical	Cat# 19136
SP2509	Cayman Chemical	Cat# 19136
Critical Commercial Assays
Ovation Ultralow System V2 1-16	NuGEN technologies	Cat# 0344NB
Papain dissociation kit	Worthington	Cat# LK003150
Dual-Glo® Luciferase Assay System	Promega	Cat# E2920
Nuclear Complex Co-IP Kit	Active Motif. Inc.	Cat# 54001
Deposited Data
ChIP-seq	This paper	GEO: GSE123652
RNA-seq	This paper	GEO: GSE123652
scRNA-Seq	This paper	GEO: GSE123652
ATAC-Seq Emx-CRE and Parv-CRE	This paper	GEO: GSE123652
Deposited Data used in the paper
ENCODE H3K27ac ChIP	Shen et al., 2012	GEO: GSE29184
ATAC-Seq human brain	Fullard et al., 2018	GEO: GSE96949
GWAS	Welter et al., 2014	http://www.ebi.ac.uk/gwas, the gwas_catalog_v1.0.1 file, accessed June 2016
SCZ GWAS	Schizophrenia Working Group of the Psychiatric Genomics, 2014	https://www.med.unc.edu/pgc/files/resultfiles/scz2.regions.zip
LoF DNMs	Turner et al., 2017	http://denovo-db.gs.washington.edu/denovo-db/
Experimental Models: Cell Lines
HEK293T	ATCC	Cat# CRL-3216
Experimental Models: Organisms/Strains
Setd1atm1a(EUCOMM)Wtsi	EMMA	Cat# EM:06857
Emx1 tm1(cre)Krj/J	Jackson Laboratory	Cat# 005628
Pvalb tm1(cre)Arbr/J	Jackson Laboratory	Cat# 017320
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J	Jackson Laboratory	Cat# 007914
C57BL/6J	Jackson Laboratory	Cat# 000664
B6N.129S6(Cg)-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/J	Jackson Laboratory	Cat# 019016
B6.Cg-Gt(ROSA)26Sortm1.3(CAG-tdTomato,-EGFP)Pjen/J	Jackson Laboratory	Cat# 026932
Oligonucleotides
Setd1a_F: GGTTATTGATCTGGGCAGGC	Sigma	N/A
Setd1a_R: TGACCTGTTTTTCAAGCCCTC	Sigma	N/A
CAS_R1_Term: TCGTGGTATCGTTATGCGCC	Sigma	N/A
Recombinant DNA
3X Mef2-Luciferase vector	Addgene	Cat# 32967
Mef2c CDS vector	Addgene	Cat# 32515
Setd1a CDS vector	Origene	Cat# MR215352
LSD1 CDS vector	Origene	Cat# MR210741
pCAG-GFP vector	Addgene	Cat# 11150
Software and Algorithms
Megablast	McGinnis and Madden, 2004)	https://blast.ncbi.nlm.nih.gov/Blast.cgi
R v3.6	R Core Team	http://www.gbif.org/resource/81287
deeptools v2.5.0.1	Ramirez et al., 2016	https://deeptools.readthedocs.io/en/develop/
Mus musculus genome version mm10	N/A	N/A
Homo sapience genome version hg38	N/A	N/A
HOMER v4.8.2	Heinz et al., 2010	http://homer.salk.edu/homer/
IDR 2.0.2	Li et al., 2011	https://github.com/nboley/idr
MACS v2.1.1	Zhang et al. 2008	https://github.com/taoliu/MACS
samtools v1.3.1	Li et al., 2009	http://samtools.sourceforge.net/
DESeq2 1.10.2	Love et al., 2014	https://bioconductor.org/packages/release/bioc/html/DESeq2.html
STAR 2.5.4b	Dobin et al., 2013	https://github.com/alexdobin/STAR
bowtie2 v2.2.6	Langmead and Salzberg, 2012	http://bowtie-bio.sourceforge.net/bowtie2/manual.shtml
Cell Ranger 2.1.1	10X Genomics	https://support.10xgenomics.com/
Seurat v. 3.0.1	Stuart*, Butler* et al., bioRxiv, 2018	https://satijalab.org/seurat/faq.html
RegioneR	Gel et al., 2016	https://www.bioconductor.org/packages/release/bioc/html/regioneR.html
Inrich	Lee et al., 2012	https://atgu.mgh.harvard.edu/inrich/
Revigo	Supek et al., 2011	http://revigo.irb.hr/
Toppgene	Chen et al 2009	https://toppgene.cchmc.org/
DNENRICH	Fromer et al., 2014	https://psychgen.u.hpc.mssm.edu/dnenrich/
CSEA tool	Dougherty et al., 2010	http://genetics.wustl.edu/jdlab/csea-tool-2/
PAVIS	Huang et al., 2013	https://manticore.niehs.nih.gov/pavis2/
Fiji	Schindelin et al., 2012	https://imagej.nih.gov/ij/download.html;
LSM Image Browser	ZEISS	https://www.embl.de/eamnet/html/body_image_browser.html
pClamp 10.3	Molecular Devices	https://www.moleculardevices.com/systems
Microsoft Excel 2013	Microsoft	https://products.office.com/en-us/excel
SigmaPlot 9.0	Systat Software Inc	http://www.sigmaplot.co.uk/products/sigmaplot/sigmaplot-details.php
GraphPad Prism	GraphPad software	https://www.graphpad.com/scientific-software/prism/
SPSS Statistics 20.0	IBM Corp.	https://www-01.ibm.com/support/docview.wss?uid=swg24029274