FIG 2.

Forest plot of the prognostic effect of the stromal tumor-infiltrating lymphocytes (TILs) variable for each 10% increment on (A) invasive disease-free survival, (B) distant disease-free survival, and (C) overall survival. Hazard ratios (HR) are derived using Cox proportional hazards regression models and presented with 95% CIs. The size of the boxes is proportional to the inverse of the variance of the estimator in each study. Cochrane Q-like test (Q) and I² statistics were used to evaluate between-study heterogeneity. BIG, Breast International Group; ECOG, Eastern Cooperative Oncology Group; FinHER, Finland Herceptin; GR, Gustave Roussy; IBCSG, International Breast Cancer Study Group; IEO, European Institute of Oncology; PACS, Protocole Adjuvant dans le Cancer du Sein.