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. Author manuscript; available in PMC: 2020 Aug 7.
Published in final edited form as: Nature. 2019 Aug 7;572(7771):676–680. doi: 10.1038/s41586-019-1472-0

Fig. 2 |. BORIS overexpression is associated with its increased chromatin occupancy in resistant cells, whereas CTCF binding is unchanged.

Fig. 2 |

a, Scatter plot of BORIS binding in sensitive (Sens) and resistant (Res) cells for all detected BORIS-binding sites. BORIS peaks unique to resistant cells (n = 21,805; 91%), sensitive cells (n = 1,125; 4.7%) and shared between the two cell types (n = 1,086; 4.5%) are shown. b, Scatter plot of CTCF binding in sensitive and resistant cells for all detected CTCF-binding sites. CTCF peaks unique to resistant cells (n = 6,808; 8.3%), sensitive cells (n = 19,129; 23.2%) and shared between the two cell types (n = 56,438; 68.5%) are shown. c, Overlap between BORIS peaks that are unique to resistant cells and CTCF peaks shared between resistant and sensitive cells (top), and between resistant cell-specific BORIS peaks and sensitive cell-specific CTCF peaks (bottom). d, Meta-analysis of average ChIP–seq signals at resistant cell-specific BORIS-binding sites. All panels, n = 2 biological replicates.