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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Brain Behav Immun. 2019 Nov 20;84:97–105. doi: 10.1016/j.bbi.2019.11.014

Figure 4.

Figure 4.

a) Relative change over time in NF-kB activity for the generativity intervention participants relative to the control condition participants, as inferred from NF-kB transcription factor-binding motifs in the promoters of differentially expressed genes (≥ 1.2-fold down or up-regulated as a function of the generativity intervention). b) Transcript origin analyses to determine cellular origins of differentially expressed genes (≥ 1.2-fold down or up-regulated as a function of the generativity intervention). Genes down-regulated as a function of the generativity (vs. control) condition (left panel) tended to derive predominately from the immature CD16− pro-inflammatory monocyte subset, whereas up-regulated genes as a function of the generativity (vs. control) condition (right panel) derived predominately from the less inflammatory and more reparative CD16+ monocyte subset.