Table 2.
Cross-trait meta-analysis results between 2 types of asthma and 3 obesity-related metabolic traits (Pmeta<5×10−8, single trait P<1×10−5)
| Model | SNP | Genome position | Effect Allele |
Ref Allele |
P1 | P2 | PMeta | Genes within clumping region |
|---|---|---|---|---|---|---|---|---|
| Later-onset asthma and BMI | rs6427082 | chr1:167179419-167393635 | T | A | 1.00×10−07 | 1.80×10−06 | 2.66×10−13 | POU2F1 |
| rs6681149 | chr1:32152518-32228004 | G | A | 6.70×10−06 | 3.30×10−10 | 2.91×10−13 | BAI2,COL16A1,MIR4254 | |
| rs72836344 | chr2:111861838-112023842 | G | T | 2.10×10−06 | 3.80×10−06 | 3.62×10−09 | ACOXL,BCL2L11 | |
| rs12493005 | chr3:176869498-176928657 | C | T | 7.00×10−06 | 3.00×10−06 | 2.44×10−11 | TBL1XR1 | |
| rs7670374 | chr4:53272753-53392903 | G | A | 4.10×10−06 | 5.70×10−07 | 4.89×10−10 | Intergenic region | |
| rs6900923 | chr6:144277568-144318433 | C | G | 3.70×10−06 | 1.30×10−06 | 4.74×10−10 | PLAGL1 | |
| rs4759229 | chr12:56379060-56609885 | A | G | 1.60×10−09 | 1.10×10−13 | 1.67×10−23 | ERBB3,ESYT1,IKZF4,MYL6, MYL6B,PA2G4,RAB5B,RNF4 1,RPL41,RPS26,SMARCC2,S UOX,ZC3H10 | |
| rs111365807 | chr17:73757836-73953404 | G | C | 3.90×10−07 | 1.40×10−07 | 7.07×10−12 | ACOX1,FBF1,GALK1,H3F3B,MIR4738,MRPL38,TRIM47,TRIM65,UNC13D,UNK,WBP2 | |
| Later-onset asthma and WHRadjBMI | rs72836349 | chr2:111861838-112023842 | T | C | 2.20×10−06 | 1.50×10−13 | 1.02×10−18 | ACOXL,BCL2L11 |
| rs1787663 | chr11:65211979-65342981 | C | A | 5.90×10−06 | 2.30×10−06 | 6.35×10−10 | FAM89B,LTBP3,MALAT1,MIR548AR,MIR548BA,MIR612,SCYL1,SSSCA1,SSSCA1-AS1 | |
| rs4616071 | chr11:111366844-111443192 | C | G | 1.40×10−06 | 1.40×10−06 | 5.85×10−12 | BTG4,C11orf88,LAYN,MIR34B,MIR34C | |
| rs10152595 | chr15:67468525-67661784 | C | G | 1.10×10−11 | 1.80×10−11 | 2.56×10−20 | AAGAB,IQCH,SMAD3 | |
| rs4842921 | chr15:84497207-84637651 | G | A | 2.70×10−06 | 3.30×10−06 | 7.60×10−11 | ADAMTSL3 | |
| rs8103278 | chr19:46219145-46374916 | G | A | 1.70×10−06 | 9.90×10−07 | 1.30×10−11 | DMPK,DMWD,FBXO46,FOXA3,LOC388553,RSPH6A,SIX5,SYMPK | |
| Later-onset asthma and FG | rs174583 | chr11:61537529-61650747 | C | T | 4.60×10−16 | 1.69×10−08 | 4.45×10−17 | FADS1,FADS2,FADS3,FEN1,MIR611,MIR1908,MIR6746,MYRF,TMEM258 |
| Non-atopic asthma and BMI | rs1381928 | chr1:8378599-8895866 | G | A | 2.30×10−07 | 2.00×10−06 | 3.90×10−10 | RERE,SLC45A1 |
| rs6681149 | chr1:32152518-32228004 | G | A | 2.80×10−06 | 3.30×10−10 | 3.17×10−13 | BAI2,COL16A1,MIR4254 | |
| rs9275570 | chr6:32428062-32681631 | G | A | 2.90×10−18 | 2.60×10−06 | 1.81×10−19 | HLA-DQA1,HLA-DQB1,HLA-DRB1,HLA-DRB5,HLA-DRB6 | |
| rs28423374 | chr7:20501204-20638155 | T | C | 9.90×10−06 | 3.70×10−07 | 2.42×10−11 | Intergenic region | |
| rs540874 | chr11:66151649-66483265 | A | G | 1.60×10−06 | 5.20×10−06 | 4.09×10−09 | ACTN3,BBS1,CCDC87,CCS,CTSF,DPP3,MRPL11,NPAS4,PELI3,RBM4,RBM4B,RBM14,RBM14-RBM4,SPTBN2,ZDHHC24 | |
| rs4759229 | chr12:56379060-56609885 | A | G | 6.90×10−09 | 1.10×10−13 | 1.75×10−21 | ERBB3,ESYT1,IKZF4,MYL6,MYL6B,PA2G4,RAB5B,RNF41,RPL41,RPS26,SMARCC2,SUOX,ZC3H10 | |
| rs111365807 | chr17:73757836-73953404 | G | C | 1.00×10−07 | 1.40×10−07 | 9.81×10−12 | ACOX1,FBF1,GALK1,H3F3B,MIR4738,MRPL38,TRIM47,TRIM65,UNC13D,UNK,WBP2 | |
| rs3826331 | chr17:38128765-38218804 | T | C | 1.40×10−08 | 2.90×10−06 | 1.13×10−12 | CSF3,GSDMA,MED24,MIR6884,PSMD3,SNORD124,THRA | |
| rs9895419 | chr17:76667271-76858539 | A | G | 7.40×10−06 | 3.60×10−06 | 1.32×10−10 | CYTH1,TIMP2,USP36 | |
| rs8089834 | chr18:39468982-39697096 | T | C | 7.60×10−06 | 4.20×10−09 | 1.46×10−13 | PIK3C3 | |
| Non-atopic asthma and WHRadjBMI | rs10152595 | chr15:67468525-67661784 | C | G | 2.80×10−12 | 1.80×10−11 | 1.40×10−20 | AAGAB,IQCH,SMAD3 |
| rs112104755 | chr18:20580534-20580534 | A | G | 3.50×10−06 | 9.00×10−06 | 6.50×10−10 | RBBP8 | |
| rs11213940 | chr11:111366844-111776891 | C | A | 4.30×10−09 | 1.60×10−06 | 1.73×10−13 | ALG9,BTG4,C11orf1,C11orf88,FDXACB1,LAYN,MIR34B,MIR34C,PPP2R1B,SIK2 | |
| rs12491785 | chr3:168679771-168905214 | C | T | 2.50×10−07 | 7.10×10−08 | 1.10×10−12 | MECOM | |
| rs73084574 | chr7:20344126-20344126 | G | A | 9.10×10−06 | 3.20×10−08 | 4.39×10−12 | LOC101927769 | |
| rs73086541 | chr7:20371232-20478448 | C | A | 1.40×10−08 | 3.10×10−11 | 6.90×10−18 | ITGB8,LOC101927811 | |
| rs73504817 | chr19:17152232-17229439 | T | C | 1.50×10−06 | 4.90×10−11 | 1.43×10−15 | HAUS8,MYO9B | |
| rs8103278 | chr19:46219145-46374916 | G | A | 4.40×10−06 | 9.90×10−07 | 5.12×10−11 | DMPK,DMWD,FBXO46,FOXA3,LOC388553,RSPH6A,SIX5,SYMPK | |
| Non-atopic asthma and FG | rs174583 | chr11:61543499-61617676 | C | T | 1.10×10−08 | 1.69×10−08 | 3.54×10−10 | FADS1,FADS2,FEN1,MIR611,MIR1908,MYRF,TMEM258 |
P1 is asthma (later-onset or non-atopic) single trait P-value, P2 is metabolic trait (BMI, WHRadjBMI or FG) single trait P-value. Pmeta is cross-trait meta-analysis P-value. FG is fasting glucose.