Table 4.
Clinical observation of control and hydrogel treated rats for acute oral toxicity study.
| Observation | Group A | Group B |
|---|---|---|
| Mean ± SEM | Mean ± SEM | |
| Body weight (g) | ||
| Pre–treatment | 205 ± 0.86 | 207 ± 1.06 |
| Day 1 | 210 ± 1.52 | 212 ± 1.30 |
| Day 7 | 215 ± 1.93 | 218 ± 2.06 |
| Day 14 | 225 ± 2.13 | 226 ± 1.80 |
| Water Intake (mL/animal/day) | ||
| Pre–treatment | 30 ± 1.40 | 28 ± 1.61 |
| Day 1 | 28 ± 1.35 | 30 ± 1.35 |
| Day 7 | 39 ± 1.36 | 40 ± 1.25 |
| Day 14 | 41 ± 1.11 | 39 ± 1.24 |
| Food Intake (g/animal/day) | ||
| Pre–treatment | 13 ± 1.65 | 16 ± 0.96 |
| Day 1 | 15 ± 1.24 | 14 ± 0.80 |
| Day 7 | 17 ± 1.35 | 16 ± 0.50 |
| Day 14 | 19 ± 1.53 | 19 ± 0.38 |
| Signs of illness | – | – |
| Dermal toxicity | – | – |
| Dermal irritation | ||
| Ocular toxicity | – | – |
| Eye Irritation | ||
| Lacrimation | – | – |
| Salivation | – | – |
| Convulsions | – | – |
| Hyperactivity | – | – |
| Touch response | + | + |
| Corneal reflex | + | + |
| Righting reflex | + | + |
| Gripping strength | + | + |
| Alertness | + | + |
| Mortality | – | – |
Results are expressed as Mean ± SEM of 5 rats in each group. Group A-Control, Group B -FCX6 hydrogel. Both at a dose of 5g/kg bodyweight. -Sign indicates lack or absence of specified observation. + Sign indicates presence of specified observations. All values have p>0.05, indicating statistically insignificant results.