Fig. 4.

Survival analysis by Kaplan–Meier curves and log-rank (Mantel–Cox) test.a Kaplan–Meier curves illustrating parameter significantly correlated with reduced survival after diagnosis of metastasis. Cut-off values were calculated by ROC analysis and Youdens’ index. Patients with > 3.5 pathogenic and likely pathogenic variants or with BRCA1 variant c.787 + 1174delA/K607fs*47/K607fs*74 (different annotations according to different BRCA1 isoforms) displayed a significant correlation with worse survival after diagnosis of metastasis. b Single variants significantly correlated with increased survival after diagnosis of metastasis. One single variant of ERBB2 and AR and three MUC16 variants were observed to increase the survival after diagnosis of metastasis highly significantly