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. 2020 Feb 10;10:2206. doi: 10.1038/s41598-020-59252-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sholl analysis of parietal layer V and VI pyramidal neurons and hippocampal CA1 neurons. Sholl analysis was performed to evaluate the amount and distribution of the dendritic arbor following bTBI. (a) In parietal cortex, there was a significant reduction in the number of dendritic intersections per shell in bTBI mice (n = 6, 54 total neurons analyzed) when compared to sham controls (n = 4, 36 total neurons analyzed) (p = 0.0002). (b) The same pattern was observed in the hippocampus, with a significant reduction in the number of dendritic intersections per shell in bTBI mice (n = 6, 54 total neurons analyzed) compared to sham controls (n = 4, 36 total neurons analyzed) (p < 0.0001).