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. 2020 Feb 10;10:2246. doi: 10.1038/s41598-020-59055-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of PSP on the expression of Klotho, Akt, FOXO3a, FGF23, p-Akt and p-FOXO3a proteins. (A) PSP increases the expression of Klotho protein (p < 0.001). (B) PSP enhances the expression of Akt protein (p < 0.01). (C) PSP decreases the expression of p-Akt protein (p < 0.001). (D) PSP increases the expression of FOXO3a protein (p < 0.001). (E) PSPdecreases the expression of FGF23 protein (p < 0.001). *p < 0.05, **p < 0.01, ***p < 0.001 vs. Control group. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. D-gal group.