Table 3.
Genotypic determinants of PCOS risk.
| Gene | SNP | Genotype | Proportion with PCOS | Unadjusted OR (95% CI) | P for unadjusted OR | Adjusted odds ratio (95% CI)a | P for main effect | P for interaction between genotype and vitamin D statusb |
|---|---|---|---|---|---|---|---|---|
| VDR | rs1544410 | CC | 143/284 (50.4%) | 0.93 (0.68, 1.26) | 0.64 | 0.78 (0.46, 1.33) | 0.37 | 0.99 |
| TC | 77/152 (50.7%) | |||||||
| TT | 11/26 (42.3%) | |||||||
| VDR | rs2228570 | GG | 56/110 (50.9%) | 0.97 (0.75, 1.25) | 0.75 | 0.93 (0.59, 1.47) | 0.76 | 0.93 |
| GA | 109/218 (50%) | |||||||
| AA | 63/127 (49.6%) | |||||||
| VDR | rs7970314 | AA | 89/173 (51.5%) | 0.99 (0.77, 1.27) | 0.92 | 0.72 (0.46, 1.15) | 0.17 | 0.99 |
| GA | 97/200 (48.5%) | |||||||
| GG | 46/89 (51.6%) | |||||||
| VDR | rs4334089 | GG | 15/31 (48.3%) | 1.03 (90.77, 1.39) | 0.82 | 0.92 (0.56, 1.52) | 0.74 | 0.30 |
| GA | 73/148 (49.3%) | |||||||
| AA | 138/275 (50.2%) | |||||||
| VDR | rs731236 | AA | 89/193 (46.1%) | 1.20 (0.92, 1.56) | 0.17 | 1.66 (1.02, 2.69) | 0.04 | 0.78 |
| GA | 106/204 (52%) | |||||||
| GG | 37/68 (54.4%) | |||||||
| VDR | rs7976091 | CC | 119/229 (52%) | 1.02 (0.78, 1.34) | 0.85 | 0.94 (0.58, 1.53) | 0.81 | 0.98 |
| TC | 78/167 (46.7%) | |||||||
| TT | 32/55 (58.2%) | |||||||
| VDR | rs2853559 | GG | 135/277 (48.7%) | 1.15 (0.85, 1.54) | 0.36 | 1.28 (0.71, 2.30) | 0.41 | 0.99 |
| GA | 81/157 (51.6%) | |||||||
| AA | 17/30 (56.6%) | |||||||
| VDR | rs7975232 | AA | 17/33 (52%) | 0.78 (0.58, 1.05) | 0.10 | 1.00 (0.57, 1.75) | >0.99 | 0.92 |
| CA | 90/162 (55.6%) | |||||||
| CC | 116/255 (45.5%) | |||||||
| VDR | rs10783219 | AA | 27/49 (55.1%) | 0.97 (90.74, 1.29) | 0.85 | 1.06 (0.65, 1.73) | 0.87 | 0.56 |
| TA | 92/198 (46.4%) | |||||||
| TT | 101/203 (49.7%) | |||||||
| VDR | rs2238136 | CC | 111/222 (50%) | 1.06 (0.81, 1.39) | 0.64 | 0.92 (0.56, 1.52) | 0.75 | 0.98 |
| TC | 79/173 (45.6%) | |||||||
| TT | 32/55 (58.2%) | |||||||
| VDR | rs4516035 | TT | 35/68 (51.5%) | 1.07 (0.82, 1.39) | 0.61 | 1.08 (0.68, 1.69) | 0.74 | 0.53 |
| TC | 95/203 (46.8%) | |||||||
| CC | 97/185 (52.4%) | |||||||
| VDR | rs11568820 | CC | 25/43 (58.1%) | 1.01 (0.77, 1.34) | 0.92 | 1.28 (0.80, 2.15) | 0.31 | 0.69 |
| TC | 68/152 (44.7%) | |||||||
| TT | 137/266 (51.5%) | |||||||
| DBP | rs2070741 | TT | 129/251 (51.4%) | 0.92 (0.68, 1.22) | 0.56 | 1.08 (0.65, 1.80) | 0.76 | 0.66 |
| GT | 83/172 (48.3%) | |||||||
| GG | 17/35 (48.6%) | |||||||
| DBP | rs7041 | AA | 46/112 (41.1%) | 1.14 (0.88, 1.47) | 0.31 | 1.20 (0.77, 1.86) | 0.41 | 0.054 |
| CA | 128/225 (57%) | |||||||
| CC | 61/126 (48.4%) | |||||||
| DBP | rs4588 | GG | 19/43 (44.2%) | 0.96 (0.73, 1.27) | 0.77 | 0.92 (0.57, 1.48) | 0.72 | 0.99 |
| TG | 98/179 (55%) | |||||||
| TT | 117/241 (49%) | |||||||
| DBP | rs16846876 | AA | 152/300 (51%) | 0.96 (0.70, 1.33) | 0.83 | 0.74 (0.41, 1.33) | 0.32 | 0.99 |
| TA | 66/139 (47.5%) | |||||||
| TT | 11/20 (55%) | |||||||
| DBP | rs2298849 | AA | 178/356 (50%) | 1.11 (0.74, 1.64) | 0.61 | 0.94 (0.45, 1.96) | 0.86 | 0.98 |
| GA | 46/97 (47.4%) | |||||||
| GG | 6/7 (86%) | |||||||
| DBP | rs12512631 | TT | 78/157 (49.6%) | 0.97 (0.76, 1.24) | 0.82 | 0.96 (0.62, 1.49) | 0.85 | 0.93 |
| TC | 105/201 (52.2%) | |||||||
| CC | 49/103 (47.6%) | |||||||
| CYP24A1 | rs6013897 | TT | 107/213 (50.2%) | 1.06 (0.81, 1.39) | 0.65 | 1.42 (0.86, 2.36) | 0.17 | 0.72 |
| TA | 96/194 (49.5%) | |||||||
| AA | 31/56 (55.4%) | |||||||
| CYP24A1 | rs2762939 | GG | 101/214 (47.2%) | 1.14 (0.88, 1.49) | 0.32 | 1.37 (0.84, 2.25) | 0.19 | 0.63 |
| GC | 104/196 (53.1%) | |||||||
| CC | 29/56 (52%) | |||||||
| CYP24A1 | rs2248137 | CC | 94/185 (51%) | 0.91 (90.70, 1.18) | 0.48 | 0.93 (0.45, 1.96) | 0.39 | 0.98 |
| GC | 101/201 (50.3%) | |||||||
| GG | 34/75 (45.3%) | |||||||
| CYP24A1 | rs2762934 | GG | 40/74 (54.1%) | 0.96 (0.75, 1.25) | 0.79 | 0.93 (0.58, 1.49) | 0.71 | 0.82 |
| GA | 97/199 (49.7%) | |||||||
| AA | 96/189 (51%) | |||||||
| CYP27B1 | rs4646536 | AA | 1/1 (100%) | 0.72 (0.32, 1.60) | 0.42 | 1.70 (0.34, 8.56) | 0.52 | 0.99 |
| GA | 12/22 (54.5%) | |||||||
| GG | 216/436 (49.5%) | |||||||
| CYP27B1 | rs4646537 | TT | 105/216 (48.6%) | 1.06 (0.80, 1.39) | 0.69 | 0.98 (0.61, 1.56) | 0.92 | 0.98 |
| GT | 97/185 (52.4%) | |||||||
| GG | 24/49 (48.9%) |
Abbreviations: PCOS, polycystic ovarian syndrome; SNP, single nucleotide polymorphism.
a, Adjusted for age, body mass index, waist-to-hip ratio, deseasonalized 25(OH)D <10 ng/ml vs ≥10 ng/ml, outdoor exercise and fasting glucose. b, P value for interaction between genotype and 25(OH)D <10 ng/ml vs ≥10 ng/ml is presented.