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. 2020 Feb 10;10:2216. doi: 10.1038/s41598-020-59237-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ER stress is elevated in ocular cicatricial pemphigoid. (a) BiP/GRP78 staining was analyzed in conjunctival biopsies of three patients with ocular cicatricial pemphigoid (OCP) and three normal subjects by immunohistochemistry. A representative image is shown for normal tissue. Consecutive sections lacking the primary antibody were used as negative controls. Scale bar, 100 μm. (b) BiP/GRP78 staining intensity in conjunctival epithelium was measured in at least two different histological areas for each subject using ImageJ. (c) Conjunctival epithelium was collected by impression cytology from nine patients with OCP and six normal subjects. The expression of MMP9 was determined by qPCR. The box and whisker plots show the 25 and 75 percentiles (box), the median, and the minimum and maximum data values (whiskers). Significance was determined using Mann-Whitney test. **p < 0.01.