Table 2.
Longitudinal effects of a single high dose of psilocybin on brain response to high conflict trials in the emotional conflict Stroop task.
| Contrast | Anatomical Region | x, y, z | k | T | Z |
|---|---|---|---|---|---|
| [CI > CC: 1 week] > [CI > CC: baseline] | L. dorsal lateral prefrontal cortex | 32, 48, 12 | 22 | 10.88 | 4.78 |
| R. medial orbitofrontal cortex | −14, 30, −12 | 40 | 10.7 | 4.75 | |
| [CI > CC: 1 month] > [CI > CC: baseline] | R. postcentral gyrus | 46, −22, 38 | 40 | 8.45 | 4.49 |
| R. fusiform gyrus | 34, −60, −8 | 22 | 7.69 | 4.31 | |
| [CI > CC: 1 week] > [CI > CC: 1 month] | L. inferior frontal gyrus (pars triangularis) | −42, 20, 24 | 114 | 7.94 | 4.23 |
| L. anterior insula | −36, 14, −12 | 52 | 7.43 | 4.11 | |
| L. inferior frontal gyrus (pars opercularis) | −56, 12, 22 | 23 | 8.23 | 4.29 | |
| L. supplementary motor area | −6, 12, 56 | 82 | 6.46 | 3.85 | |
| L. premotor area | −28, 6, 46 | 21 | 5.5 | 3.55 | |
| L. inferior parietal lobule | −40, −54, 40 | 34 | 6.14 | 3.76 | |
| L. fusiform gyrus | −40, −46, −24 | 67 | 5.79 | 3.65 | |
| L. fusiform gyrus | −40, −54, −14 | 33 | 7.04 | 4.01 | |
| R. fusiform gyrus | 34, −50, −22 | 27 | 6.69 | 3.92 |
Significant clusters from whole-brain voxel-wise contrasts for high-demand incongruent (CI) greater than low-demand congruent (CC) trials [CI > CC], compared between 1 week and baseline ([CI > CC: 1 week] > [CI > CC: baseline]), and 1 week and 1 month ([CI > CC: 1 week] > [CI > CC: 1 month]) were thresholded at p(unc) < 0.0005, k ≥ 20. L: left; R: right; x, y, z: coordinates of the peak voxel in each cluster; k: cluster size. Anatomical regions for each cluster were determined using the SPM Anatomy Toolbox and the Duvernoy Brain Atlas. Whole-brain analyses were thresholded at p < 0.0005 (uncorrected), with cluster-forming threshold of p < 0.05 (uncorrected).