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. 2020 Feb 10;10:2252. doi: 10.1038/s41598-020-58680-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypertension related target gene screening. (A) The significant GO terms that conformed to a P < 0.05 were screened. (B) Fisher’s exact test was used to select the significant pathway, identified by a P < 0.05. GO, Gene ontology; BP, Biological process; CC, Cellular component; MF, Molecular function. (C) Venn diagrams of DGEs mRNA in the hypertension related gene set, Online Mendelian Inheritance in Man (OMIM), Genetic Association Database (GAD), the Human Gene Database (MalaCards), Disease Gene Search with Evidence Sentences (Digsee), genome-wide association studies (GWAS). (D) Venn diagrams of significantly upregulated or downregulated mRNAs in the hypertension related gene control compared with HCMV. (E) Venn diagrams of significantly upregulated or downregulated mRNAs in the hypertension related gene Control compared with HG + ox-LDL. (F) Venn diagrams of significantly upregulated or downregulated mRNAs in the hypertensionrelated gene HCMV + HG + ox-LDL compared with HCMV. (G) Venn diagrams of significantly upregulated or downregulated mRNAs in the hypertensionrelated gene HCMV + HG + ox-LDL compared with HG + ox-LDL.