Table 2.
Risk of dementia among patients with cancer stratified by anatomical site.
| Cancer types | O | SIR*(95% CI) | |
|---|---|---|---|
| Oral (upper aerodigestive tract) | 228 |  |
0.76 (0.66–0.86) |
| Salivary gland | 34 | 1.03 (0.71–1.43) | |
| Esophageal | 16 | 0.34 (0.19–0.56) | |
| Stomach | 110 | 0.59 (0.48–0.71) | |
| Small intestine | 46 | 0.74 (0.54–0.99) | |
| Colon | 1,272 | 0.81 (0.77–0.86) | |
| Rectum | 568 | 0.71 (0.65–0.77) | |
| Anus | 29 | 0.75 (0.50–1.08) | |
| Liver | 34 | 0.39 (0.27–0.54) | |
| Pancreas | 18 | 0.30 (0.18–0.47) | |
| Nose | 21 | 1.05 (0.65–1.61) | |
| Lung | 260 | 0.65 (0.57–0.73) | |
| Breast | 2,124 | 0.86 (0.82–0.90) | |
| Cervix | 65 | 0.85 (0.65–1.08) | |
| Endometrium | 558 | 0.80 (0.73–0.86) | |
| Ovary | 113 | 0.60 (0.49–0.72) | |
| Other female genitals | 60 | 0.82 (0.62–1.05) | |
| Prostate | 3,724 | 0.76 (0.73–0.78) | |
| Testis | 12 | 1.22 (0.63–2.14) | |
| Other male genitals | 26 | 0.73 (0.48–1.07) | |
| Kidney | 251 | 0.73 (0.64–0.83) | |
| Urinary bladder | 972 | 0.87 (0.81–0.92) | |
| Melanoma | 538 | 0.72 (0.66–0.78) | |
| Skin | 1,478 | 0.87 (0.83–0.92) | |
| Eye | 30 | 0.70 (0.47–1.00) | |
| Nervous system | 228 | 0.98 (0.86–1.11) | |
| Thyroid gland | 54 | 0.76 (0.57–0.99) | |
| Endocrine glands | 319 | 1.03 (0.92–1.15) | |
| Connective tissue | 65 | 0.81 (0.63–1.04) | |
| Non-Hodgkin's lymphoma | 538 | 0.75 (0.69–0.82) | |
| Hodgkin's disease | 16 | 0.72 (0.41–1.17) | |
| Myeloma | 124 | 0.78 (0.64–0.92) | |
| Leukemia | 159 | 0.80 (0.68–0.94) | |
| Smoking-related# | 1920 | 0.76 (0.72–0.79) | |
| Non-smoking-related | 12,170 | 0.80 (0.78–0.81) | |
| All | 14,090 | 0.79 (0.78–0.80) |
*
Adjusted for age, sex, education, birth country, period of dementia diagnosis, diabetes, and hypertension.
#
Defined as cancer of the oral, esophageal, stomach, pancreas, lung, cervix, kidney, and urinary bladder.
Bold values indicate SIR less than 1 and 95% CI does include 1.00.