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. 2020 Feb 4;10:73. doi: 10.3389/fonc.2020.00073

Table 4.

Risk of dementia among patients with cancer stratified by different kinds of dementia.

Cancer types Alzheimer's Vascular dementia Other dementia
O SIR* 95% CI O SIR* 95% CI O SIR* 95% CI
Oral (upper aerodigestive tract) 78 0.87 0.69–1.08 65 0.70 0.54–0.89 85 0.73 0.58–0.90
Salivary gland 18 1.76 1.04–2.79 5 0.50 0.16–1.18 11 0.85 0.42–1.52
Esophageal 3 0.22 0.04–0.64 4 0.28 0.07–0.71 9 0.49 0.22–0.93
Stomach 31 0.58 0.40–0.93 34 0.59 0.41–0.82 45 0.61 0.44–0.81
Small intestine 11 0.56 0.28–1.01 13 0.69 0.37–1.18 22 0.94 0.59–1.42
Colon 425 0.90 0.81–0.98 348 0.74 0.67–0.83 499 0.80 0.73–0.87
Rectum 185 0.78 0.67–0.90 160 0.65 0.56–0.76 223 0.71 0.62–0.81
Anus 8 0.63 0.27–1.24 7 0.66 0.29–1.37 14 0.98 0.54–1.61
Liver 9 0.33 0.15–0.63 9 0.34 0.15–0.64 16 0.47 0.27–0.77
Pancreas 1 0.05 0.00–0.30 4 0.22 0.06–0.58 13 0.57 0.30–0.98
Nose 5 0.82 0.26–1.92 10 1.70 0.81–3.14 6 0.75 0.27–1.64
Lung 90 0.69 0.56–0.85 65 0.55 0.42–0.70 105 0.68 0.56–0.83
Breast 824 0.91 0.85–0.97 527 0.86 0.79–0.94 773 0.82 0.76–0.88
Cervix 20 0.74 0.46–1.15 13 0.70 0.35–1.15 32 1.05 0.72–1.49
Endometrium 205 0.83 0.72–0.95 144 0.78 0.66–0.92 209 0.78 0.68–0.90
Ovary 54 0.80 0.60–1.04 22 0.46 0.29–0.70 37 0.50 0.35–0.69
Other female genitals 19 0.82 0.49–1.28 14 0.73 0.40–1.22 27 0.87 0.57–1.27
Prostate 1127 0.80 0.75–0.85 1262 0.77 0.73–0.82 1335 0.72 0.68–0.76
Testis 2 0.66 0.06–2.44 4 1.21 0.31–3.13 6 1.71 0.62–3.75
Other male genitals 10 1.03 0.49–1.91 7 0.58 0.23–1.21 9 0.65 0.29–1.24
Kidney 83 0.78 0.62–0.97 82 0.76 0.60–0.94 86 0.69 0.55–0.84
Urinary bladder 282 0.87 0.77–0.98 325 0.89 0.80–1.00 365 0.85 0.76–0.94
Melanoma 175 0.70 0.60–0.81 158 0.72 0.61–0.84 205 0.74 0.64–0.85
Skin 448 0.89 0.81–0.98 448 0.90 0.82–0.98 582 0.84 0.78–0.92
Eye 11 0.80 0.40–1.43 7 0.55 0.22–1.14 12 0.72 0.37–1.27
Nervous system 59 0.73 0.55–0.94 51 0.77 0.57–1.02 118 1.39 1.15–1.66
Thyroid gland 16 0.66 0.38–1.07 16 0.79 0.45–1.29 22 0.82 0.51–1.24
Endocrine glands 102 1.00 0.82–1.22 94 1.03 0.83–1.26 123 1.07 0.89–1.27
Connective tissue 16 0.66 0.38–1.07 22 0.92 0.57–1.39 27 0.85 0.56–1.24
Non-Hodgkin's lymphoma 164 0.73 0.62–0.85 147 0.70 0.59–0.83 227 0.82 0.72–0.93
Hodgkin's disease 5 0.69 0.22–1.63 6 0.88 0.32–1.93 5 0.61 0.19–1.42
Myeloma 37 0.76 0.54–1.05 34 0.71 0.49–0.99 53 0.84 0.63–1.09
Leukemia 52 0.82 0.61–1.08 50 0.87 0.64–1.15 57 0.76 0.58–0.99
Smoking related# 588 0.77 0.71–0.84 592 0.75 0.69–0.81 740 0.76 0.71–0.82
Non-smoking related 3987 0.84 0.81–0.86 3565 0.78 0.76–0.81 4618 0.78 0.76–0.81
All 4575 0.82 0.80–0.85 4157 0.78 0.75–0.80 5358 0.78 0.76–0.80
*

Adjusted for age, sex, education, birth country, period of dementia diagnosis, diabetes, and hypertension.

#

Defined as cancer of the oral, esophageal, stomach, pancreas, lung, cervix, kidney, and urinary bladder.

Bold values indicate SIR less than 1 and 95% CI does include 1.00.