TABLE 1.
Characteristics of the study population.
| Patient (N = 215) | Control (N = 205) | P value | |
| Female, n (%) | 135 (62.79%) | 121 (59.02%) | 0.429 |
| Male, n (%) | 80 (37.21%) | 84 (40.98%) | – |
| Age at examination (years, mean ± SD) | 73.67 ± 7.23 | 70.74 ± 7.82 | 0.128a |
| Age at onset | 71.95 ± 8.46 | – | |
| EOAD, n (%) | 49 (22.79%) | – | |
| Femaleb, n (%) | 34 (69.39%) | – | |
| Education level (years, mean ± SD) | 8.35 ± 4.96 | 10.73 ± 3.96 | <0.001 |
| MMSE score (mean ± SD) | 15.33 ± 5.96 | 28.80 ± 1.24 | <0.001 |
| CDT score (mean ± SD) | 1.61 ± 1.47 | 3.94 ± 0.24 | <0.001 |
| APOE genotype (%) | |||
| ε2/ε2 | 2 (0.93%) | 1 (0.49%) | |
| ε2/ε3 | 11 (5.12%) | 23 (11.22%) | |
| ε2/ε4 | 7 (3.26%) | 2 (0.98%) | |
| ε3/ε3 | 89 (41.40%) | 136 (66.34%) | |
| ε3/ε4 | 83 (38.60%) | 42 (20.49%) | |
| ε4/ε4 | 23 (10.70%) | 1 (0.49%) | |
| APOE ε4 carriers | 113 (52.56%) | 45 (21.95%) | <0.001 |
AD, Alzheimer’s disease; Control, healthy controls; MMSE, Mini-Mental State Examination; CDT, clock drawing test; APOE, apolipoprotein E, APOE ε4 carriers have at least one copy of the ε4 allele; SD, standard deviation a: P value was compared with the age of onset for AD patients and age at examination for control subjects. b: Referred to EOAD. Bold indicates statistically significant values.