TABLE 4.

Effect of rs9271058 on HLA-DRB1 gene expression in different regions of normal human brain in GTEx.

Variant ID	Tissue	Samples	Genotype			P-value	NES
			AA	AT	TT
chr6_32607629_A_T_b38	Brain – Cerebellum	209	11	95	103	4.2×10–23	–0.72
	Brain-Caudate (basal ganglia)	194	11	80	103	1.6×10–16	–0.45
	Brain – Cortex	205	12	86	107	2.5×10–15	–0.53
	Brain – Putamen (basal ganglia)	170	11	79	80	1.3×10–14	–0.54
	Brain – Nucleus accumbens (basal ganglia)	202	10	83	109	4.6×10–13	–0.46
	Brain – Frontal Cortex (BA9)	175	7	76	92	1.3×10–12	–0.52
	Brain – Cerebellar Hemisphere	175	7	76	92	7.5×10–12	–0.57
	Brain – Anterior cingulate cortex (BA24)	147	8	67	72	1.8×10–11	–0.54
	Brain – Hypothalamus	170	8	69	93	1.2×10–8	–0.34
	Brain – Amygdala	129	5	50	74	8.9×10–8	–0.33
	Brain – Hippocampus	165	8	66	91	1×10–6	–0.27
	Brain – Spinal cord (cervical c-1)	126	7	51	68	1.4×10–5	–0.30

Samples: The number of RNA-seq samples with genotype, P-value: from a t-test that compares observed NES from single-tissue eQTL analysis to a null NES of 0, NES: Normalized Effect Size, the slope of the linear regression of normalized expression data versus the three genotype categories using single-tissue eQTL analysis representing eQTL effect size.