Table 1.
Physiological values of the model's parameters for an adult rat.
| Parameters | Description | Value | References |
|---|---|---|---|
| PBCSFB | BCSFB influx permeability coefficient to sodium (from blood to CSF) | 3.8 × 10−5 (cm s−1) | Smith and Rapoport, 1986 |
| ABCSFB | Surface area of BCSFB | 1 (cm2) | Smith and Rapoport, 1986 |
| BCSFB efflux permeability coefficient to sodium (from CSF to blood) | 6.9 × 10−7 cm s−1 | Calculated | |
| Vs | Subarachnoid space volume |
0.2 (cm3) | Smith and Rapoport, 1986; Brøchner et al., 2015 |
| Vv | Ventricular system volume | 0.1 (cm3) | Smith and Rapoport, 1986; Brøchner et al., 2015 |
| Vb | Brain tissue volume | 1.1 (cm3) | Sahin et al., 2011 |
| PBBB | BBB influx permeability coefficient to sodium (from blood to brain tissue) | 1.4 × 10−7 (cm s−1) | Smith and Rapoport, 1986 |
| ABBB | Surface area of the BBB | 140 (cm2 g−1) | Smith and Rapoport, 1986 |
| BBB efflux permeability coefficient to sodium (from brain tissue to blood) | 1.35 × 10−7 cm s−1 | Calculated | |
| fd | Sodium distribution factor | 0.34 (cm3 g−1) | Smith and Rapoport, 1986 |
| D | Diffusion coefficient of sodium in the brain ISF | 1.15 × 10−5 (cm2 s−1) | Goodman et al., 2005 |
| Qcsf | CSF flow rate | 3.6 × 10−5 (cm3 s−1) | Smith and Rapoport, 1986 |
| Pvb | Permeability coefficient of the contact surface of brain tissue and ventricular system to sodium | 106 (cm s−1) | A large value was used |
| Psb | Permeability coefficient of the contact surface of brain tissue and subarachnoid space to sodium | 106 (cm s−1) | A large value was used |
| λ | ISF/brain volume fraction | 0.2 (dimensionless) | Smith and Rapoport, 1986; Lei et al., 2017 |
| ρ | Rat brain density | 1 (g cm−3) | Smith and Rapoport, 1986 |