Table 3.
Odds ratios (OR) and 95% confidence interval (CI) for associations between body shape from childhood to inclusion and risk of breast cancer, overall.
| Cases/controls | Model 1 - matcheda | Model 2 - fully adjustedb | |
|---|---|---|---|
| OR (95% CI) | OR (95% CI) | ||
| Silhouette between 6 and 11 | |||
| 1 | 256/232 | 1.00 (ref.) | 1.00 (ref.) |
| 2 | 84/109 | 0.69 (0.49–0.98) | 0.61 (0.39–0.95) |
| 3 | 40/40 | 0.92 (0.57–1.48) | 0.98 (0.52–1.86) |
| ≥4 | 26/25 | 0.93 (0.52–1.65) | 1.02 (0.48–2.18) |
| P-trend | 0.39 | 0.61 | |
| Silhouette between 12 and 18 | |||
| 1 | 133/127 | 1.00 (ref.) | 1.00 (ref.) |
| 2 | 165/164 | 0.96 (0.68–1.35) | 1.14 (0.73–1.78) |
| 3 | 77/78 | 0.95 (0.63–1.43) | 0.83 (0.49–1.42) |
| ≥4 | 31/37 | 0.80 (0.47–1.37) | 1.03 (0.52–2.03) |
| P-trend | 0.47 | 0.68 | |
| Silhouette between 19 and 25 | |||
| 1 | 66/54 | 1.00 (ref.) | 1.00 (ref.) |
| 2 | 178/151 | 0.98 (0.64–1.49) | 1.19 (0.70–2.04) |
| 3 | 92/127 | 0.59 (0.38–0.93) | 0.70 (0.39–1.26) |
| ≥4 | 70/74 | 0.79 (0.49–1.27) | 1.09 (0.58–2.05) |
| P-trend | 0.05 | 0.56 | |
| Silhouette before first pregnancy (parous women) | |||
| 1 | 79/77 | 1.00 (ref.) | 1.00 (ref.) |
| 2 | 128/117 | 1.05 (0.70–1.56) | 0.75 (0.45–1.25) |
| 3 | 64/68 | 0.92 (0.57–1.47) | 0.74 (0.40–1.36) |
| ≥4 | 33/42 | 0.78 (0.45–1.35) | 0.57 (0.27–1.19) |
| P-trend | 0.31 | 0.15 | |
| Silhouette between age 26 and 1 year before inclusion | |||
| 1–2 | 118/77 | 1.00 (ref.) | 1.00 (ref.) |
| 3 | 140/114 | 0.77 (0.52–1.14) | 0.97 (0.58–1.60) |
| 4 | 73/102 | 0.44 (0.28–0.68) | 0.42 (0.24–0.76) |
| ≥5 | 69/107 | 0.39 (0.25–0.61) | 0.45 (0.25–0.79) |
| P-trend | <0.01 | <0.01 | |
| Silhouette at interview | |||
| 1–2 | 128/82 | 1.00 (ref.) | 1.00 (ref.) |
| 3 | 141/108 | 0.79 (0.53–1.17) | 0.82 (0.49–1.35) |
| 4 | 72/96 | 0.43 (0.27–0.67) | 0.44 (0.25–0.77) |
| ≥5 | 65/120 | 0.31 (0.20–0.49) | 0.33 (0.19–0.59) |
| P-trend | <0.01 | <0.01 | |
| Trajectory | |||
| T1 ‘Increase at puberty' | 125/115 | 1.00 (ref.) | 1.00 (ref.) |
| T2 ‘Constant increase - lean' | 234/239 | 0.90 (0.65–1.23) | 1.03 (0.68–1.56) |
| T3 ‘Constant increase - overweight' | 47/52 | 0.82 (0.51–1.33) | 0.91 (0.49–1.70) |
Abbreviations: CI, confidence interval; OR, odds ratio.
aOdds ratios were estimated by logistic regression conditioned on age (±3 years), city district of residence, and health insurance institution.
bAdditionally adjusted for education (≤primary/secondary/>secondary), history of benign breast disease (yes/no), family history of breast cancer (yes/no), total physical activity (tertiles), number of full-term pregnancies (0/1/≥2), age at first full-term pregnancy (tertiles/nulliparous/missing), cumulated duration of breastfeeding (</≥ 12 months), age at menarche (</≥ 12 years old), smoking status (current/former/never), diabetes (yes/no), daily alcohol intake (tertiles/non-consumer), height (tertiles). Only women with available information on height were included in the analyses for model 2.