Table 1.

Residual activity of rFAAH and hFAAH in the presence of prototypical FAAH inhibitors, at a homodimer:inhibitor stoichiometric ratio of 1:2.

	rFAAH (% of specific activity)	hFAAH (% of specific activity)
CTRL	100.0 ± 4.2§	100 ± 1.0#
URB597	3.5 ± 0.8***	36 ± 2.0**
MAFP	2.0 ± 0.5***	0.31 ± 0.01***
PF-750	2.9 ± 0.3***	53 ± 11**
PF-3845	1.9 ± 0.6***	0.24 ± 0.01***
OL-135	4.3 ± 0.9***	62 ± 8**
ST4070	4.3 ± 1.3***	68 ±` 4**

^§rFAAH control specific activity 78.3 ± 9.6 nmol/min per mg of the protein.

^#hFAAH control specific activity 15.9 ± 2.0 nmol/min per mg of the protein.

**P < 0.01 versus hFAAH.

***p < 0.0001 versus rFAAH or hFAAH.

Data on rFAAH inhibition by URB597 are from Fig. 1, and are included for the sake of clarity.