Table 2.

Residual activity of rFAAH and hFAAH in the presence of prototypical FAAH inhibitors, at a homodimer:inhibitor stoichiometric ratio of 1:1.

	rFAAH (% of specific activity)	hFAAH (% of specific activity)
Control	100.0 ± 4.2§	100 ± 1.0#
URB597	2.3 ± 1.3***	23.0 ± 3.0**
MAFP	3.5 ± 0.4***	5.0 ± 9.0**
PF-750	3.6 ± 0.2***	49.0 ± 3.0**
PF-3845	3.8 ± 0.2***	2.0 ± 3.0***
OL-135	6.8 ± 1.0***	59.0 ± 12.0**
ST4070	6.9 ± 0.5***	64.0 ± 17.0**

^§rFAAH control specific activity 78.3 ± 9.6 nmol/min per mg of protein.

^#hFAAH control specific activity 15.9 ± 2 nmol/min per mg of the protein.

**p < 0.01 versus hFAAH.

***p < 0.0001 versus rFAAH or hFAAH.

Data on rFAAH inhibition by URB597 were reported for the sake of clarity, and were taken from Fig. 1.