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. 2020 Feb 10;11:809. doi: 10.1038/s41467-020-14595-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Cells with H3, H3K4A, set1Δ, bre2Δ, and spp1Δ on the rad53-K227A background were arrested in G1 and released into 25 mM of HU for 2 h. The cellular DNA content was determined by FACS at the indicated time-points. Purple slanted arrows indicate faster replication progression in mutant cells compared to H3 cells. b The graphs show DNA Pol2 binding profiles centered on ORC-bound early or late ARSs in RAD53-H3, RAD53-H3K4A, rad53-K227A-H3, and rad53-K227A-H3K4A cells. c ATAC-seq signals on TSSs ± 0.5 kb regions after G1-release in 25 mM HU. d Spearman’s rank correlation coefficient of ATAC-seq signals according c. e ATAC-seq signals on TSS regions (−0.1 to 0.5 kb). f ATAC-seq signals on ORC-bound origins.