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. 2020 Feb 10;8:6. doi: 10.1038/s41413-019-0077-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — ELISA analysis of the protein expressions of inflammatory factors and MMPs in vivo and the expression of NF-κB p65 and IκBα as detected by western blot. a, b ELISA results of IL-1β, TNF-α, and MMP3 protein expression in joint fluid from rats in each group at 1 and 2 months. Statistical analysis: (^*) compared to the sham group; ^*P < 0.05, ^**P < 0.01. (^{^}) Compared to the KOA + NS group; ^{^^}P < 0.01. (^#) Compared to the KOA + T group; ^#P < 0.05, ^##P < 0.01. (^&) Compared to the KOA + wogonin group; ^&P < 0.05, ^&&P < 0.01. c Comparison of the 1-month and 2-month data for the protein expression of IL-1β, TNF-α, and MMP3. Statistical analysis: (*) compared to the sham group (1 month); *P < 0.05, ^**P < 0.01. (^{^}) Compared to the KOA + NS group (1 month); ^{^^}P < 0.01. (^#) Compared to the KOA + T group (1 month); ^##P < 0.01. (^&) Compared to the KOA + wogonin group (1 month); ^&P < 0.05, ^&&P < 0.01. (^a) Compared to the sham group (2 months); ^aaP < 0.01. (^b) Compared to the KOA + NS group (2 months); ^bbP < 0.01. (^c) Compared to the KOA + T group (2 months); ^cP < 0.05, ^ccp < 0.01. (^$) Compared to the KOA + wogonin group (2 months); ^$$P < 0.01. (T, TFNA; W, wogonin.) d Protein expression of NF-κB p65 and IκBα was analyzed by western blot analysis. e, f Quantification of NF-κB p65 and IκBα expression using a t test. Statistical analysis: (^*) compared to the control group; ^*P < 0.05, ^**P < 0.01, ^***P < 0.001. (^{^}) Compared to the IL-1β group; ^{^}P < 0.05, ^{^^}P < 0.01