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. 2020 Feb 10;10:2257. doi: 10.1038/s41598-020-59039-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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YL exhibits an antidepressant-like effect in mice. (a–c) Antidepressant-like effect of YL. YL ((a) 0.1–30 mg/kg, i.p.; (b) 0.1–1.0 nmol/mouse, i.c.v.; (c) 30–100 mg/kg, p.o.) was administered to mice, and the immobility time during a 4-min forced swim test (FST) session was measured 30 min after administration (n = 11; n = 8–9; n = 18, respectively). (d) Antidepressant-like activity of YL was comparable to those of already-known antidepressants. Immobility time during a 4-min FST session was measured after the administration of YL, fluvoxamine, and imipramine (30 mg/kg, i.p.) in mice (n = 7–8). (e) Antidepressant-like effect of YL (10–30 mg/kg, i.p.) in the tail suspension test (TST) (n = 6).