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. 2020 Feb 10;10:2257. doi: 10.1038/s41598-020-59039-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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YL activates the 5-HT_1A, dopamine D₁, and GABA_A systems. Effect of serotonin 5-HT_1A, dopamine D₁, and GABA_A antagonist on YL-induced antidepressant-like activity. WAY100135 dihydrochloride, a serotonin 5-HT_1A receptor antagonist (10 mg/kg), R(+)-SCH-23390 hydrochloride, a dopamine D₁ receptor antagonist (30 mg/kg), or (−)-bicuculline (5 mg/kg) or flumazenil, antagonists of GABA- and benzodiazepine-binding sites of GABA_A receptors, respectively (1 mg/kg), was co-administered once intraperitoneally with the peptide 30 min before FST. Values are expressed as the mean ± S.E.M. (n = 9–10). Different characters represent significant differences (P < 0.05) among each group by ANOVA followed by Tukey-Kramer’s test.