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. 2020 Feb 10;10:2257. doi: 10.1038/s41598-020-59039-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antidepressant-like activity of the structure-activity relationship of YL. (a) Immobility time during a 4-min FST session when YL, LY, Y, and L (30 mg/kg body weight) were administered intraperitoneally to mice (n = 7–8). Value are expressed as the means ± S.E.M. Asterisks show significant differences between the YL-administered group and the vehicle-administered group. *P < 0.05 as determined by ANOVA. (b) Structure-activity relationship of the antidepressant-like effect of YL in the FST. YL, FL, and WL (30 mg/kg, i.p.) were administered to mice and immobility time during a 4-min FST session was measured (n = 7–8). (c) YLG (10–100 mg/kg, i.p.) and YL (30 mg/kg, i.p.) were administered to mice, and immobility time during a 4-min FST session was measured 30 min after administration (n = 7–8).