Figure 1.

Acarbose protected against collagen-induced arthritis. DBA/1 mice were treated with acarbose or miglitol or water either 7 days prior to (A), Before Induction or at the time of arthritis induction (day 0) (B), At Induction. Incidence and severity of arthritis were evaluated until day 55 post arthritis induction. (C) Joints of mice were harvested and stained with hematoxylin and eosin (H&E) and safranin-O. Representative photographs of histopathology showing synovitis, pannus formation, and marginal erosion of the joint and articular architectural changes in normal joint and mild, moderate and severe arthritis (pooled data of two experiments, n = 10–15 mice in each group). *p < 0.01; **p < 0.05.