Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Specific deletion of Prdm12 from POMC neurons impairs hypothalamic Pomc expression. Immunofluorescence performed in sagittal cryosections of E15.5 embryos using an anti-ACTH antibody in the mediobasal hypothalamic (Hyp) and Rathke's pouch (Rp) areas. POMCPrdm12KO embryos show less and very dim POMC neurons compared with Prdm12loxP/loxP controls whereas POMC cells in the future pituitary remain intact. Bottom, magnified views of the hypothalamic areas boxed in the figures above.
