Table 1.

Percentage rates previously reported for longitudinal changes in FA and MD. Each row shows the detected longitudinal percentage change in a metric's average over a specific brain region in subjects from the same clinical population. Clinical conditions: amyotrophic lateral sclerosis (ALS), mild cognitive impairment (MCI), frontotemporal dementia (FTD), Alzheimer's disease (AD) and primary progressive multiple sclerosis (ppMS). Brain regions: corticospinal tract (CST), the body of the corpus callosum (CC body), left and right uncinate fascicle (UF), right parahippocampal cingulum (PH-CING) and cerebellar, frontal and occipital white matter (WM) .

Study	Condition	Brain Region	Metric	% change	Time
Study	Condition	Brain Region	Metric	% change	Time
Blain et al. 2007	ALS	CST	FA	−2.70%	6 months
Teipelet al. 2010	MCI	CC body	FA	−2.50%	12 months
Mahoney et al. 2015	FTD	CC body	FA	−3.30%	12 months
		UFLeft	FA	−7.90%	12 months
Kitamura et al., al. 2013	AD	UF Right	FA	−3.20%	18 months
		UF Left	FA	−4.50%	18 months
Blain et al. 2007	ALS	CST	MD	0.58%	6 months
Mahoney et al. 2015	FTD	PH-CING Right	MD	2.70%	12 months
		UF Left	MD	5.20%	12 months
Schmiereret al. 2004	ppMS	Cerebellar WM	MD	2.30%	12 months
		Frontal WM	MD	2.70%	12 months
		Occipital WM	MD	3.60%	12 months