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. 2020 Jan 31;10:1678. doi: 10.3389/fphar.2019.01678

Figure 3.

Figure 3

Platelet activation and alpha-granule secretion is inhibited by myricetin but not by gallic acid. Washed platelets (WP) were pre-treated with myricetin or GA for 10 min, stimulated with agonists, and incubated with FITC-coupled fibrinogen and PE/PerCP anti-P-selectin antibodies. Fibrinogen binding (A) and P-selectin exposure (B) of CRP-activated platelets treated with myricetin. Fibrinogen binding (C) or Pselectin exposure (D) of CRP-activated platelets treated with GA. Fibrinogen binding (E) and P-selectin exposure (F) of TRAP-6-activated platelets treated with myricetin. Fibrinogen binding (G) and P-selectin exposure (H) of TRAP-6-activated platelets treated with GA. a p < 0.05 vs first column of graph. b p < 0.05 vs second column of graph. c p < 0.05 vs third column of graph. Data analyzed by paired one-way ANOVA and Tukey as post-test. All bar graphs represent mean ± SEM as well as individual data points of at least three independent experiments.