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Flow chart of the present study. Toothbrush and oral samples were obtained from the participants treated with traditional Chinese medicinal toothpaste and antibacterial toothpaste, respectively. A high-throughput sequencing method was used to analyse species richness. Genera showing a significant increase compared with other groups are shown with ↑; those showing a highly significant increase are shown with ↑↑. The increased risks of human disease for each group are shown.
