Figure 2.

A schematic view of the effects of cellular senescence in renal diseases. In renal diseases, various types of cells may experience senescence such as endothelial cells and renal tubular epithelial cells (RTECs). Although senescence may have protective effects in the development of autosomal dominant polycystic kidney disease (ADPKD), acute phase of acute kidney disease (AKI) and renal fibrosis, senescence can promote the progression of several renal diseases, including AKI, diabetic nephropathy, glomerulonephritis, renal fibrosis and dysfunction of transplant kidney