Table 2. Metabolite Univariate Analysis^a.

molecule	survivors (702)	deceased (123)	P-value	P-value adjusted
creatinine	196.6 ± 52.2	261.0 ± 108.5	1.05 × 10–10	2.53 × 10–09
proline	115.2 ± 60.0	154.8 ± 95.3	3.43 × 10–07	4.11 × 10–06
formate	9.4 ± 3.4	11.4 ± 3.8	3.10 × 10–06	2.48 × 10–05
unknown	10.2 ± 11.6	19.8 ± 21.2	5.94 × 10–06	3.56 × 10–05
valine	1122.6 ± 237.2	1026.2 ± 257.4	6.67 × 10–05	3.20 × 10–04
3-hydroxybutyrate	329.1 ± 320.1	487.1 ± 523.7	4.83 × 10–04	1.93 × 10–03
mannose	105.4 ± 34.5	1229 ± 55.9	8.27 × 10–04	2.84 × 10–03
histidine	114.2 ± 21.6	106.9 ± 23.7	3.84 × 10–03	1.15 × 10–02
acetate	78.9 ± 47.1	97.9 ± 67.2	7.54 × 10–03	1.85 × 10–02
acetone	735.2 ± 559.6	900.44 ± 824.9	7.71 × 10–03	1.85 × 10–02
isobutyrate	30.3 ± 12.0	35.54 ± 14.6	9.18 × 10–03	2.00 × 10–02
citrate	89.7 ± 29.8	99.84 ± 39.6	1.23 × 10–02	2.47 × 10–02
glutamine	188.3 ± 46.5	203.89 ± 71.3	1.69 × 10–02	2.98 × 10–02
glucose	2765.7 ± 745.9	3037.1 ± 1067.3	1.74 × 10–02	2.98 × 10–02
isoleucine	162.0 ± 42.4	151.6 ± 41.0	2.55 × 10–02	4.08 × 10–02
phenylalanine	227.84 ± 58.7	231.1 ± 63.9	4.85 × 10–02	7.27 × 10–02
alanine	1488.5 ± 364.0	1395.3 ± 323.2	7.04 × 10–02	9.93 × 10–02
glutamate	205.5 ± 105.7	181.0 ± 114.1	8.69 × 10–02	1.16 × 10–01
glycine	522.18 ± 162.0	478.2 ± 157.4	1.21 × 10–01	1.53 × 10–01
methionine	109.6 ± 34.8	115.9 ± 43.2	2.54 × 10–01	3.04 × 10–01
leucine	520.9 ± 119.0	508.6 ± 146.7	3.33 × 10–01	3.80 × 10–01
lactate	1515.5 ± 416.4	1578.3 ± 611.9	8.55 × 10–01	8.98 × 10–01
tyrosine	169.1 ± 36.9	169.5 ± 45.7	8.60 × 10–01	8.98 × 10–01
creatine	101.9 ± 60.0	100.1 ± 80.7	9.61 × 10–01	9.61 × 10–01

^aList of metabolites assigned and quantified in the serum NMR spectra, reported as median with median absolute deviation (arbitrary units). A P-value adjusted with the Benjamini–Hochberg correction <0.05 is deemed significant.