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. 2020 Feb 10;24:46. doi: 10.1186/s13054-020-2753-6

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Relationship between plasma concentration and rate of appearance and clearance of lactate. Relation between plasma lactate concentrations and rate of appearance of lactate (upper panel) and metabolic clearance of lactate (bottom panel) as calculated from a bolus dose of ¹³C-labeled lactate in healthy volunteers (blue circles, n = 6) and ICU patients (red circles, n = 10). The lines of regression and associated statistics apply to the group of ICU patients only