Table 5.
Subgroup analysis results of genetic variants with statistically significance (P-value< 5*10−8) from GWAS studies based on migraine subtype
| Author, year | Gene/variant | Comparison | OR (95%CI) | P-value | Subtypes | No. of cases/controls | FPRP Values at Prior probability | BFDP 0.001 | BFDP 0.000001 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR 1.2 | OR 1.5 | |||||||||||
| 0.001 | 0.000001 | 0.001 | 0.000001 | |||||||||
| Gormley P, 2016 [40] | LRP1/rs11172113 | C vs. T | 0.85 (0.82–0.89) | 4.3E-16 | MO | 8348/139622 | 5.365E-09 | 5.370E-06 | 4.295E-09 | 4.300E-06 | 4.578E-07 | 4.580E-04 |
| Gormley P, 2016 [40] | FHL5/rs7775721 | T vs. A | 1.15 (1.11–1.20) | 1.1E-12 | MO | 8348/139622 | 1.253E-07 | 1.254E-04 | 1.222E-07 | 1.223E-04 | 1.210E-05 | 0.012 |
| Gormley P, 2016 [40] | ASTN2/rs6478241 | G vs. A | 1.14 (1.09–1.18) | 1.2E-10 | MO | 8348/139622 | 9.555E-11 | 9.565E-08 | 9.538E-11 | 9.548E-08 | 1.305E-08 | 1.307E-05 |
| Gormley P, 2016 [40] | TRPM8/rs6724624 | G vs. C | 0.86 (0.82–0.90) | 1.1E-09 | MO | 8348/139622 | 8.654E-08 | 8.662E-05 | 7.899E-08 | 7.906E-05 | 7.681E-06 | 7.630E-03 |
| Gormley P, 2016 [40] | PHACTR1/rs9349379 | G vs. A | 0.88 (0.85–0.92) | 2.1E-09 | MO | 8348/139622 | 1.748E-05 | 0.017 | 1.733E-05 | 0.017 | 1.395E-03 | 0.583 |
| Gormley P, 2016 [40] | FGF6/rs1024905 | A vs. G | 1.12 (1.08–1.16) | 2.5E-09 | MO | 8348/139622 | 2.451E-07 | 2.453E-04 | 2.451E-07 | 2.453E-04 | 2.680E-05 | 0.026 |
| Gormley P, 2016 [40] | TSPAN2/rs2078371 | C vs. T | 1.18 (1.12–1.25) | 7.4E-09 | MO | 8348/139622 | 2.525E-05 | 0.025 | 1.808E-05 | 0.018 | 1.276E-03 | 0.561 |
| Anttila V, 2013 [29] | TRPM8/rs6741751 | A vs. G | 0.80 (0.75–0.86) | 8.64E-11 | MO | 7107/69427 | 1.094E-05 | 0.011 | 1.469E-06 | 1.469E-03 | 1.143E-04 | 0.103 |
| Anttila V, 2013 [29] | LRP1/rs11172113 | C vs. T | 0.87 (0.84–0.91) | 9.96E-11 | MO | 7107/69427 | 1.300E-06 | 1.300E-03 | 1.260E-06 | 1.260E-03 | 1.117E-04 | 0.101 |
| Anttila V, 2013 [29] | PHACTR1/rs9349379 | G vs. A | 0.86 (0.82–0.90) | 2.81E-10 | MO | 7107/69427 | 8.654E-08 | 8.662E-05 | 7.899E-08 | 7.906E-05 | 7.681E-06 | 7.630E-03 |
| Anttila V, 2013 [29] | FHL5/rs11759769 | A vs. G | 1.18 (1.13–1.24) | 1.58E-12 | MO | 7107/69427 | 8.181E-08 | 8.189E-05 | 6.109E-08 | 6.115E-05 | 5.781E-06 | 5.753E-03 |
| Anttila V, 2013 [29] | MMP16/rs10504861 | T vs. C | 0.86 (0.81–0.90) | 1.17E-08 | MO | 7107/69427 | 8.654E-08 | 8.662E-05 | 7.899E-08 | 7.906E-05 | 7.681E-06 | 7.630E-03 |
GWAS genome-wide association studies, MO migraine without aura