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. 2020 Feb 11;18:66. doi: 10.1186/s12967-020-02256-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The expression and correlation of TCTP and vimentin in human lung tumor tissues. a The levels of TCTP and vimentin in 109 paired NSCLC tissues and adjacent normal tissues. The stained tissues were examined using the Zeiss Spot imaging system and the immunohistochemical staining scored was assessed and expressed as Mean with range. Wilcoxon signed ranks test was used to compare the values between tumor tissues and non-tumor tissues. b Negative relationship of TCTP with lung cancer patient outcomes on OS (overall survival) and RFS (recurrence-free survival). The OS of the two groups of patients (n = 1926) with high and low TCTP expression in NSCLC and the RFS of the two groups of patients (n = 726) with high and low TCTP expression in NSCLC tissues were analyzed based on online survival analysis software: Kaplan–Meier plotter. TCTP high level is significantly related to poor OS and poor RFS in lung cancer patients. c Positive correlation of TCTP and vimentin expression in lung tumor. The correlation of expression levels of TCTP and vimentin in 109 NSCLC tumor tissues scored were analyzed. A positive correlation between TCTP and vimentin expression level in lung tumor were shown. d TCTP and vimentin expression in human lung tumor tissues and non-tumor tissues. TCTP and vimentin protein levels were examined in 6 randomly selected paired NSCLC specimens. The quantification of protein was carried out by densitometry analysis, and the result was presented by the relative intensity of each of non-tumor condition based on actin normalization for total protein. The relative intensity of protein bands was summarized by column figure. The values indicate the mean ± SD of three independent experiments (N stands for non-tumor tissue, T stands for tumor tissue; *p < 0.05 and **p < 0.01 vs. N condition). 3 out of 6 and 4 out of 6 of patients showed higher levels of TCTP and vimentin respectively in tumor tissues than that in adjacent normal tissues. A positive correlation between TCTP and vimentin level in 5 patients’ lung tumor were found