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. 2020 Feb 10;10(1):2045894019897513. doi: 10.1177/2045894019897513

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© The Author(s) 2020

Creative Commons CC-BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 1. — The study design summarized. Male Sprague Dawley rats (n = 32) were divided into two groups (n = 16 in each group). Group 1: Sugen–hypoxia (SuHx)—a single dose of Sugen-5416, before being placed in a hypobaric chamber for two weeks and then placed in normal room pressure for three weeks whilst PH developed, animals receive control chow throughout. Group 2: normoxic maintained at normal room pressure for five weeks. In each group, half the animals entered the cardiac MRI arm of the study (n = 8) while the other half underwent right heart catheterization for hemodynamic assessment (n = 8). Animals were assessed at five weeks and eight weeks from the beginning of the study with right heart catheterization, CMR, and gross anatomy at autopsy.