Table 4.
Factors of gastrointestinal perforation stratified by fluoroquinolones subgroup in different tracking period by using Cox regression
| Tracking period | Fluoroquinolones subgroup | Populations | Events | PDs | Rate (per 105 PDs) | Adjusted HR | 95% CI | 95% CI | P | Adjusted HR | 95% CI | 95% CI | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3-day | Without | 133,684 | 2 | 23,707,602.75 | 0.01 | Reference | Reference | ||||||
| With | 33,421 | 0 | 5,940,776.06 | 0.00 | 0.000 | – | – | 0.995 | |||||
| Levofloxacin | 653 | 0 | 112,735.69 | 0.00 | 0.000 | – | – | 0.960 | |||||
| Ciprofloxaxin | 1843 | 0 | 316,411.56 | 0.00 | 0.000 | – | – | 0.978 | |||||
| Moxifloxacin | 139 | 0 | 24,500.00 | 0.00 | 0.000 | – | – | 0.988 | |||||
| Gemifloxacin | 12 | 0 | 2160.00 | 0.00 | 0.000 | – | – | 0.998 | |||||
| Norfloxacin | 7041 | 0 | 1,261,596.87 | 0.00 | 0.000 | – | – | 0.996 | |||||
| Ofloxacin | 23,733 | 0 | 4,223,371.94 | 0.00 | 0.000 | – | – | 0.990 | |||||
| 7-day | Without | 133,684 | 6 | 23,707,602.75 | 0.03 | Reference | Reference | ||||||
| With | 33,421 | 1 | 5,940,776.06 | 0.02 | 0.512 | 0.080 | 27.426 | 0.756 | |||||
| Levofloxacin | 653 | 0 | 112,735.69 | 0.00 | 0.000 | – | – | 0.982 | |||||
| Ciprofloxaxin | 1843 | 0 | 316,411.56 | 0.00 | 0.000 | – | – | 0.979 | |||||
| Moxifloxacin | 139 | 0 | 24,500.00 | 0.00 | 0.000 | – | – | 0.993 | |||||
| Gemifloxacin | 12 | 0 | 2160.00 | 0.00 | 0.000 | – | – | 0.986 | |||||
| Norfloxacin | 7041 | 0 | 1,261,596.87 | 0.00 | 0.000 | – | – | 0.978 | |||||
| Ofloxacin | 23,733 | 1 | 4,223,371.94 | 0.02 | 0.776 | 0.114 | 72.301 | 0.442 | |||||
| 14-day | Without | 133,684 | 10 | 23,707,602.75 | 0.04 | Reference | Reference | ||||||
| With | 33,421 | 3 | 5,940,776.06 | 0.05 | 1.025 | 0.044 | 1.356 | 0.111 | |||||
| Levofloxacin | 653 | 0 | 112,735.69 | 0.00 | 0.000 | – | – | 0.986 | |||||
| Ciprofloxaxin | 1843 | 1 | 316,411.56 | 0.32 | 1.572 | 0.052 | 7.166 | 0.678 | |||||
| Moxifloxacin | 139 | 0 | 24,500.00 | 0.00 | 0.000 | – | – | 0.995 | |||||
| Gemifloxacin | 12 | 0 | 2160.00 | 0.00 | 0.000 | – | – | 0.986 | |||||
| Norfloxacin | 7041 | 1 | 1,261,596.87 | 0.08 | 1.342 | 0.020 | 6.988 | 0.501 | |||||
| Ofloxacin | 23,733 | 1 | 4,223,371.94 | 0.02 | 0.427 | 0.035 | 4.972 | 0.494 | |||||
| 28-day | Without | 133,684 | 14 | 23,707,602.75 | 0.06 | Reference | Reference | ||||||
| With | 33,421 | 4 | 5,940,776.06 | 0.07 | 1.137 | 0.090 | 1.498 | 0.157 | |||||
| Levofloxacin | 653 | 0 | 112,735.69 | 0.00 | 0.000 | – | – | 0.978 | |||||
| Ciprofloxaxin | 1843 | 1 | 316,411.56 | 0.32 | 1.266 | 0.028 | 2.999 | 0.267 | |||||
| Moxifloxacin | 139 | 0 | 24,500.00 | 0.00 | 0.000 | – | – | 0.978 | |||||
| Gemifloxacin | 12 | 0 | 2160.00 | 0.00 | 0.000 | – | – | 0.964 | |||||
| Norfloxacin | 7041 | 1 | 1,261,596.87 | 0.08 | 2.052 | 0.184 | 22.485 | 0.532 | |||||
| Ofloxacin | 23,733 | 2 | 4,223,371.94 | 0.05 | 0.307 | 0.555 | 1.752 | 0.188 | |||||
| 3-month | Without | 133,684 | 45 | 23,707,602.75 | 0.19 | Reference | Reference | ||||||
| With | 33,421 | 12 | 5,940,776.06 | 0.20 | 1.049 | 0.156 | 1.925 | 0.198 | |||||
| Levofloxacin | 653 | 0 | 112,735.69 | 0.00 | 0.000 | – | – | 0.952 | |||||
| Ciprofloxaxin | 1843 | 1 | 316,411.56 | 0.32 | 1.076 | 0.013 | 1.972 | 0.129 | |||||
| Moxifloxacin | 139 | 0 | 24,500.00 | 0.00 | 0.000 | – | – | 0.978 | |||||
| Gemifloxacin | 12 | 0 | 2160.00 | 0.00 | 0.000 | – | – | 0.986 | |||||
| Norfloxacin | 7041 | 3 | 1,261,596.87 | 0.24 | 1.472 | 0.402 | 5.411 | 0.524 | |||||
| Ofloxacin | 23,733 | 8 | 4,223,371.94 | 0.19 | 0.390 | 0.145 | 1.786 | 0.379 | |||||
| 6-month | Without | 133,684 | 68 | 23,707,602.75 | 0.29 | Reference | Reference | ||||||
| With | 33,421 | 17 | 5,940,776.06 | 0.29 | 1.330 | 0.778 | 2.276 | 0.255 | |||||
| Levofloxacin | 653 | 0 | 112,735.69 | 0.00 | 0.000 | – | – | 0.975 | |||||
| Ciprofloxaxin | 1843 | 1 | 316,411.56 | 0.32 | 1.402 | 0.197 | 10.121 | 0.702 | |||||
| Moxifloxacin | 139 | 0 | 24,500.00 | 0.00 | 0.000 | – | – | 0.966 | |||||
| Gemifloxacin | 12 | 0 | 2160.00 | 0.00 | 0.000 | – | – | 0.973 | |||||
| Norfloxacin | 7041 | 3 | 1,261,596.87 | 0.24 | 0.911 | 0.348 | 3.526 | 0.813 | |||||
| Ofloxacin | 23,733 | 13 | 4,223,371.94 | 0.31 | 1.442 | 0.793 | 2.601 | 0.199 |
PDs Person-days, Adjusted HR Adjusted hazard ratio: Adjusted for the variables listed in Table 2, CI Confidence interval