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. 2020 Jan 30;2020:5919501. doi: 10.1155/2020/5919501

Figure 4.

Figure 4

Reduced β-amyloid but unaltered CREB and BDNF in resistance-trained 3xTg-AD mice. (a) Representative immunoblots for amyloid precursor protein (APP) and β-amyloid probed in hippocampal homogenate. The shorter and longer exposure clearly revealed APP (110 to 85 kDa) and Aβ oligomer (25 kDa) bands, respectively. (b) Amyloid precursor protein (APP) normalized to tubulin. (c) β-Amyloid expression normalized to tubulin. (d) Representative immunoblots for CREB and BDNF expression. (e) p-CREB normalized to total CREB. (f) BDNF expression normalized to β-actin. Data presented as mean ± SE. Tissues assayed from the nonexercised group (Tg), the aerobic-trained group (Tg+AT), or the resistance-trained group (Tg+RT) (n = 10/group). Differences determined by one-way ANOVA. ∗p < 0.05 and ∗∗p < 0.01.