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. 2020 Feb 10;20:112. doi: 10.1186/s12885-020-6598-9

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Hypermethylation of the FLT1 promoter in cells and a tissue from choriocarcinoma. a Schematic diagram of the genomic structure of the FLT1 gene. Numbers indicate the position relative to the transcription start site (TSS) of FLT1. The vertical lines represent the location of CpG dinucleotides. The thick bar indicates a typical CpG island in the FLT1 promoter. b Methylation patterns in the promoter region of FLT1. The 23 CpG sites of FLT1 were analyzed by bisulfite sequencing. The DNA methylation data were analyzed by the QUMA methylation analysis tool (http://quma.cdb.riken.jp/). Open circles and closed circles represent unmethylated and methylated CpG sites, respectively. Numbers indicate the position relative to the TSS. Numbers in parentheses represent the overall percentage of methylated CpG sites