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. 2020 Feb 10;21:47. doi: 10.1186/s12931-020-1307-4

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Average FEV₁ over 0–12 h (full analysis set). Data are least squares means treatment–placebo differences and 95% confidence intervals. *p < 0.05; ^†p < 0.01; ^‡p < 0.001 vs placebo. Least squares mean changes from baseline in the placebo group (N = 79) were 8 and −33 mL on Day 1 and at Week 4, respectively. Abbreviation: FEV₁, forced expiratory volume in 1 s