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. 2020 Feb 10;20:45. doi: 10.1186/s12935-020-1137-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Ubiquitin-specific peptide 22 (USP22) was upregulated in gastric cancer tissue and correlated with T stage in patients. a Immunohistochemical staining of USP22 expression. The study included 88 samples of paired primary gastric cancer tissue (left) and adjacent normal tissue (right). Representative images are shown. Magnification ×100. b Quantification of a. c The mRNA expression of USP22 in 90 samples from The Cancer Genome Atlas database, including 19 samples of normal gastric tissue, 65 samples of gastric adenocarcinoma tissue, and 6 samples of gastrointestinal stromal tumor tissue. d Kaplan–Meier analysis of survival time in patients with gastric cancer (n = 88)