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. 2020 Feb 10;12:24. doi: 10.1186/s13148-020-0818-7

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — H3K27me3 and EZH2 expression of melanoma metastases prior to anti-PD-1 therapy. a H3K27me3 and EZH2 expression of melanoma metastases (in %) in correlation to response to anti-PD-1 inhibition. Significance was determined by Χ² test for categorical data. b Percentage of H3K27me3-positive melanoma cells in correlation to percentage of EZH2-positive melanoma cells. Significance was determined by Spearman’s rank correlation test (p = .002)