Table 2.
Association of miR-15b-3p Expression in GC with Different Clinicopathological Features
| Variables | Exo-miR-15b-3p expression | P-value | |
|---|---|---|---|
| Low(n = 54) | High(n = 54) | ||
| Age, years | 0.425 | ||
| <60 | 22(40.7%) | 18(33.3%) | |
| ≥ 60 | 32(59.3%) | 36(66.7%) | |
| Gender | 0.661 | ||
| Male | 41(75.9%) | 39(72.2%) | |
| Female | 13(24.1%) | 15(27.8%) | |
| Smoking | 0.311 | ||
| Yes | 16(29.6%) | 21(38.9%) | |
| No | 38(70.4%) | 33(61.1%) | |
| Alcohol abuse | 0.024* | ||
| Yes | 8(14.8%) | 18(33.3%) | |
| No | 46(85.2%) | 36(66.7%) | |
| Family history of cancer | 0.206 | ||
| Yes | 7(13.0%) | 12(22.2%) | |
| No | 47(87.0%) | 42(77.8%) | |
| Size, cm | 0.020* | ||
| <3.5 | 30(55.6%) | 18(33.3%) | |
| ≥ 3.5 | 24(44.4%) | 36(66.7%) | |
| Location | 0.267 | ||
| Cardia | 16(29.6%) | 11(20.4%) | |
| Non-cardia | 38(70.4%) | 43(79.6%) | |
| Lauren’s classification | 0.101 | ||
| Intestinal type | 22(40.7%) | 14(25.9%) | |
| Diffuse type | 20(37.0%) | 31(57.4%) | |
| Mixed type | 12(22.2%) | 9(16.7%) | |
| Histological grade | 0.011* | ||
| Well differentiated | 22(40.7%) | 10(18.5%) | |
| Poor differentiated | 32(59.3%) | 44(81.5%) | |
| Invasion depth | 0.176 | ||
| T1/2 | 28(51.9%) | 21(38.9%) | |
| T3/4 | 26(48.1%) | 33(61.1%) | |
| Tumor stage | 0.002* | ||
| I,II | 38(70.4%) | 22(40.7%) | |
| III,IV | 16(29.6%) | 32(59.3%) | |
| Lymphovascular invasion | 0.001* | ||
| Negative | 37(68.5%) | 20(37.0%) | |
| Positive | 17(31.5%) | 34(63.0%) | |
*P < 0.05