Table 2.
Resistance-associated mutations (RAMs) and other substitutions found in the integrase region along with the susceptibility score
| Subject | Major | Accessory | Other | Score RAL | Score EVG | Score DTG | Score BIC |
|---|---|---|---|---|---|---|---|
| 1 | Y143R | T97A | L101I, V201I, S230N | 70 | 25 | 5 | 5 |
| 2 | – | – | K111R, T125A, T206S, S230N, D232E | 0 | 0 | 0 | 0 |
| 3 | – | – | I72V, L101I, T124A, V126T, I135V, F181L, V201I, K215N, D232E | 0 | 0 | 0 | 0 |
| 4 | – | – | A80V, L101I, T112V, T124N, T125V, I141V, G163E, V201I, I203M | 0 | 0 | 0 | 0 |
| 5 | G140S, Q148H | – | L101I, T112A, T124A, T125A, I135V, K156N, D256E | 90 | 90 | 45 | 45 |
| 6 | E92Q, E138K, Y143HR | – | L68V, L74M, S119T, V201I, S230N, D232E, L234F | 105 | 90 | 30 | 30 |
| 7 | – | – | L101I, K111R, T112S, R187K | 0 | 0 | 0 | 0 |
| 8 | G140S, Y143R, Q148H | – | L101I, K160N, L234I | 150 | 100 | 50 | 50 |
| 9 | – | – | I113V, T124N, T125A, K211R, K219N, N222K, D232E, D253E | 0 | 0 | 0 | 0 |
| 10 | – | – | V31I, M50L, L101I, T112I, V201I | 0 | 0 | 0 | 0 |
| 11 | – | – | D25E, V31I, I72V, Y99F, L101I, T124A, T125A, I135V, G163T | 0 | 0 | 0 | 0 |
| 12 | Y143H | – | F1I, D3V, V31I, Q44P, I72V, I73T, L102FPS, G106A, S230N, D256E | 60 | 10 | 5 | 5 |
| 13 | – | E157Q | S17N, A21E, A23V, L28I, P30A, S39C, I113V, T124A, T125A, K160R, V201I, L234I, W243G, D253E, S255N | 10 | 10 | 0 | 0 |
| 14 | E138K, G140A, Q148K | – | V31I, I72V, K111R, V201I, I208M, K215N, I220L | 120 | 120 | 80 | 80 |
| 15 | – | – | L101I, K136N, V151I, V201I, T206S, E212V, K215N, D256E, S283G | 0 | 0 | 0 | 0 |
| 16 | Y143R | G163R | V31I, L74M, Y99F, G106A, T112A, I113V, S123V, T124A, T125A, I204V, S230N, K240R | 75 | 35 | 15 | 15 |
| 17 | E92Q, N155H | G163R | V31I, L101I, T112AIV, T124A, E138D, V151I, K211R | 105 | 135 | 25 | 25 |
| 18 | – | – | S24N, T124A, K160Q, V201I, S230N | 0 | 0 | 0 | 0 |
| 19 | Y143C, N155H | S230R | K14R, V31I, E69Q, Y99F, L101I, S119T, T124A, I135V, G163E, K211R, L234V, D256E | 140 | 95 | 40 | 30 |
| 20 | N155H | G163R | T112A, T124A, I135V, V151I, K156R, V201I, I208M | 75 | 75 | 10 | 10 |
| 21 | N155H | – | I72V, L101I, S119R, V151I, K156N, I208L, E212L, T218S | 60 | 60 | 10 | 10 |
| 22 | – | – | L68M, T122S, T124A, V151I, G193E, I208L | 0 | 0 | 0 | 0 |
| 23 | N155H | – | L101I, K111T, S119T, T124A, T125A, I208L | 60 | 60 | 10 | 10 |
| 24 | – | – | L101I, K111T, I113V, S119P, K211R, K219N, N222K, S230N | 0 | 0 | 0 | 0 |
| 25 | – | – | I72V, I73V, A80V, L101I, K111R, T124A, E138D, G163V, G197W, R228K | 0 | 0 | 0 | 0 |
Stanford HIV Drug Resistance Database v8.8. N = 25
RAMs resistance-associated mutations, RAL raltegravir, EVG elvitegravir, DTG dolutegravir, BIC bictegravir