Table 1.
Screening of lipid formulations of MSN/siRNA+miRNA+ICG.
| 1) Single lipid species | ||||||
|---|---|---|---|---|---|---|
| Formulation | (-) | SPC | mDSPE-PEG | Chol | DPPC | DSPC |
| Stabilization effect (h) | 0.1–0.2 | 6–10 | 8–12 | 2–4 | 0.5–1 | 0.5–1 |
| 2) Two lipids species (w/w, 1:1) | |||
|---|---|---|---|
| Formulation | SPC + mDSPE-PEG | SPC + Chol | mDSPE-PEG + Chol |
| Stabilization effect (h) | >48 | 4–6 | 24–48 |
| 3) Ratio of SPC and mDSPE-PEG | |||
|---|---|---|---|
| Ratio (w/w) | 2:1 | 1:1 | 1:2 |
| Stabilization effect (h) | 24–48 | >48 | >48 |
| 4) Three lipids species (w/w, 2:2:1)c | ||
|---|---|---|
| Formulation | SPC + mDSPE-PEG + DSPE-PEG-DBCO | SPC + mDSPE-PEG + Chol |
| Stabilization effect (h) | >48 | 24–48 |