Adverse event by SOC/PT	Grade 1, n (%)	Grade 2, n (%)	Grade 3, n (%)	Grade 4, n (%)	All grades, n (%)
Hematologic	2 (11)	2 (11)	1 (6)	0 (0)	4 (22)
Anemia	0 (0)	1 (6)	0 (0)	0 (0)	1 (6)
Leukopenia	1 (6)	0 (0)	0 (0)	0 (0)	1 (6)
Lymphopenia	1 (6)	1 (6)	1 (6)	0 (0)	3 (17)
General	16 (89)	4 (22)	1 (6)	0 (0)	18 (100)
Fatigue	2 (11)	1 (6)	0 (0)	0 (0)	3 (17)
Induration	2 (11)	0 (0)	0 (0)	0 (0)	2 (11)
Injection site bruising	6 (33)	0 (0)	0 (0)	0 (0)	6 (33)
Injection site erythema	15 (83)	2 (11)	0 (0)	0 (0)	17 (94)
Injection site extravasation	1 (6)	0 (0)	0 (0)	0 (0)	1 (6)
Injection site induration	10 (56)	0 (0)	0 (0)	0 (0)	10 (56)
Injection site irritation	2 (11)	0 (0)	0 (0)	0 (0)	2 (11)
Injection site edema	1 (6)	0 (0)	0 (0)	0 (0)	1 (6)
Injection site pain	10 (56)	2 (11)	1 (6)	0 (0)	13 (72)
Injection site pruritus	14 (78)	1 (6)	0 (0)	0 (0)	15 (83)
Injection site reaction	2 (11)	0 (0)	0 (0)	0 (0)	2 (11)
Injection site scab	2 (11)	0 (0)	0 (0)	0 (0)	2 (11)
Injection site swelling	11 (61)	3 (17)	0 (0)	0 (0)	14 (78)
Injection site warmth	6 (33)	1 (6)	0 (0)	0 (0)	7 (39)
Pain	4 (22)	0 (0)	0 (0)	0 (0)	4 (22)
Nervous system	1 (6)	0 (0)	0 (0)	0 (0)	1 (6)
Headache	1 (6)	0 (0)	0 (0)	0 (0)	1 (6)
Skin	3 (17)	0 (0)	0 (0)	0 (0)	3 (17)
Blister	1 (6)	0 (0)	0 (0)	0 (0)	1 (6)
Pruritus	1 (6)	0 (0)	0 (0)	0 (0)	1 (6)
Rash	1 (6)	0 (0)	0 (0)	0 (0)	1 (6)
Urticaria	1 (6)	0 (0)	0 (0)	0 (0)	1 (6)
Vascular	0 (0)	1 (6)	0 (0)	0 (0)	1 (6)
Hypotension	0 (0)	1 (6)	0 (0)	0 (0)	1 (6)
Total	17 (94)	7 (39)	2 (11)	0 (0)	18 (100)

Treatment‐emergent adverse events attributed to HyperAcute Renal.

If a subject experienced more than one event within a given SOC, that subject was counted once for that SOC. If a subject experienced more than one event within a given PT, that subject was counted only once for that PT. The most severe event is counted.

Abbreviations: PT, preferred term; SOC, system organ class.